Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help in Treatment for Breast Cancer

Not Applicable

Completed

• Conditions: Breast Cancer
• Interventions: Other: Vo2max measurements; Other: Mindfulness-based-stress-reduction; Other: Endurance exercise training; Other: Both interventions together; Genetic: Telomerase activity on a blood sample; Other: Quality of life (questionnaires); Other: Cerebral IRMf

• Registration Number: NCT02900326
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Integrative approaches to promote wellness and reduce the distress associated with cancer are considered as essential components of cancer care. In case, exercise training has been shown to produce many positive physiological and psychological benefits. Mindfulness-based stress reduction program shows similar beneficial effects, and especially in emotional distress management. The aim of the study is to examine the cumulative effect of an 8 week-exercise-training program combined with an MBSR program on cardio-respiratory fitness and quality of life in women with breast cancer. These effects are thought to be mediated in part through changes in underlying brain processes, that investigators will be put in light. Through telomerase activity, oxidative stress, mitochondrial respiration and blood cytokine level measurements, investigators could expect to better understand the effect of these combined training in breast cancer.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05-12
• Primary Completion: 2015-05-12
• Study First Submitted: 2015-06-16
• Study First Submitted QC: 2016-09-13
• Study First Posted: 2016-09-14
• Study Completion: 2021-03-30
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-17
• Last Update Posted: 2022-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Breast cancer
• Having completed the chemotherapy period
• Undergoing radiotherapy and/or hormono therapy

Exclusion Criteria

• Regular physical activity higher than 4 hours per week.
• Any disease cardiac, respiratory, neurological or articular disease, which counteract the muscular training )

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control patients with no intervention	Vo2max measurements	group without intervention
Control patients with no intervention	Telomerase activity on a blood sample	group without intervention
Control patients with no intervention	Quality of life (questionnaires)	group without intervention
MBSR group (mindfulness-based-stress-reduction)	Mindfulness-based-stress-reduction	only mental training group (8 weeks)
Endurance training program (8 weeks) group	Cerebral IRMf	only physical training group
Endurance training program (8 weeks) group	Vo2max measurements	only physical training group
Endurance training program (8 weeks) group	Quality of life (questionnaires)	only physical training group
Endurance training program (8 weeks) group	Telomerase activity on a blood sample	only physical training group
Control patients with no intervention	Cerebral IRMf	group without intervention
Endurance training program (8 weeks) group	Endurance exercise training	only physical training group
Endurance training program combined with MBSR sessions	Both interventions together	Endurance training program combined with MBSR sessions, during 8 weeks (mindfulness-based-stress-reduction)

Primary Outcome Measures

Name	Time	Method
Evolution of V02 max between inclusion and 8 weeks	8 weeks	effect of physical training associated with mental work on physical abilities of patients

Trial Locations

Locations (1)

Physiologie et EFR/ EA 3072 mitochondrie, stress oxydant et protection musculaire; 🇫🇷 Strasbourg, France