Influence of Physical Exercise as Adjuvant Treatment in Patients With Alzheimer's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- European University Miguel de Cervantes
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- Short Physical Performance Battery
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this non-randomized clinical trial is to assess the effects of strength training in the physical function of Alzheimer's disease (AD) patients. The main question it aims to answer are:
- Is a basic strength training enough to improve physical function in AD patients?
- Is an exercise intervention able to delayed the progression of the disease?
- Is an AMRAP intervention feasible in AD patients?
Participants in the exercise group will perform a 16-weeks program divided in two phases (phase 1: basic strength training; phase 2: AMRAP training). Participants in both (exercise and control) groups will receive their usual care treatments which include occupational therapy, musicotherapy, cognitive stimulation and sensory stimulation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •MMSE (Mini-Metal State Examination) score of ≥15 out of 35 (at screening less than 2 months prior to baseline visit)
- •Age ≥60 years old
- •Be able to walk with or without aids
- •Be able to follow verbal instructions
Exclusion Criteria
- •Surgery in the last 3 months
- •Exhibit clear signs of disorientation
- •Clinically confirmed signs of aggressiveness
Outcomes
Primary Outcomes
Short Physical Performance Battery
Time Frame: 0 weeks, 12 weeks, 16 weeks of intervention. 8 weeks of detraining
Changes in the SPPB Score (Short Physical Performance Battery; Range between 0 "worst performance" and 12 "best performance")
Secondary Outcomes
- Handgrip strength(0 weeks, 12 weeks, 16 weeks of intervention. 8 weeks of detraining)
- Body mass index(0 weeks, 12 weeks, 16 weeks of intervention. 8 weeks of detraining)
- Practicability of AMRAP (As Many Repetitions As Possible) training; it will be analysed by calculating both intra- and inter-subject coefficient variation.(Every session (during 13 sessions))