Influence of Physical Exercise as Adjuvant Treatment in Patients With Alzheimer's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Short Physical Performance Battery
研究概览
简要总结
The goal of this non-randomized clinical trial is to assess the effects of strength training in the physical function of Alzheimer's disease (AD) patients. The main question it aims to answer are:
- Is a basic strength training enough to improve physical function in AD patients?
- Is an exercise intervention able to delayed the progression of the disease?
- Is an AMRAP intervention feasible in AD patients?
Participants in the exercise group will perform a 16-weeks program divided in two phases (phase 1: basic strength training; phase 2: AMRAP training). Participants in both (exercise and control) groups will receive their usual care treatments which include occupational therapy, musicotherapy, cognitive stimulation and sensory stimulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
The persons analyzing the data collected (investigators, statician) will not know to which group each person belongs.
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •MMSE (Mini-Metal State Examination) score of ≥15 out of 35 (at screening less than 2 months prior to baseline visit)
- •Age ≥60 years old
- •Be able to walk with or without aids
- •Be able to follow verbal instructions
排除标准
- •Surgery in the last 3 months
- •Exhibit clear signs of disorientation
- •Clinically confirmed signs of aggressiveness
结局指标
主要结局
Short Physical Performance Battery
时间窗: 0 weeks, 12 weeks, 16 weeks of intervention. 8 weeks of detraining
Changes in the SPPB Score (Short Physical Performance Battery; Range between 0 "worst performance" and 12 "best performance")
次要结局
- Handgrip strength(0 weeks, 12 weeks, 16 weeks of intervention. 8 weeks of detraining)
- Body mass index(0 weeks, 12 weeks, 16 weeks of intervention. 8 weeks of detraining)
- Practicability of AMRAP (As Many Repetitions As Possible) training; it will be analysed by calculating both intra- and inter-subject coefficient variation.(Every session (during 13 sessions))