Study of swelling in blood vessels of ski
- Conditions
- Health Condition 1: L959- Vasculitis limited to the skin, unspecified
- Registration Number
- CTRI/2020/01/022981
- Lead Sponsor
- GCS Medical College Hospital and Research Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients of either sex and of all age group.
Patient presenting clinical sign and symptoms suggestive of cutaneous vasculitis or
vasculopathy like,
1) Palpable purpura
2) Petechiae
3) Macular purpura
4)Urticarial papules
5) Vesicles
6)Pustules
7)Targeted papules and plaques
8) Livedo racemosa
9)Retiform purpura
10)Ulcers
11)Subcutaneous nodules
12)Digital necrosis
13)Erythema
14)Cyanotic skin
15)Livedo reticularis
16)Atrophie blanche
17)Ecchymotic streak
18)Any other on PI discretion.
1)All patient not willing to give consent
2)Any systemic vascultis case without cutaneous manifestations.
Patients having pre-existing or detected during study work up any other disease which
mimic cutaneous vasculitis and diseases involving vessel walls other than livido
vasculopathy and malignant atrophic papulosis will be excluded from final analysis.
Following is list of such disorders.( this is not definite list any other compounding
factor on PI discretion will be excluded from final analysis.)
3)Patient with hemostatically relevant thrombocytopenia (<50,000/cu mm) in following
condition:
Idiopathic thrombocytopenic purpura
Thrombotic thrombocytopenic purpura
Disseminated intravascular coagulation
Thrombocytopenia due to 1) drug related peripheral destruction (eg quinine, quinidine)
2) Drug induced decreased production, idiosyncratic or dose related (eg chemotherapy) 3)
Bone marrow infiltration, fibrosis or failure
4) Patient with congenital or hereditary platelet function defects
5)Patient with acquired platelet function defects due to 1) Aspirin, NSAIDs 2) Renal
insufficiency 3) Monoclonal gammopathy
6)Patient with thrombocytosis secondary to myeloproliferative disorders (often >1000000/cu
mm)
7)Patient with occlusion primarily due to microvascular platelet plugs like heparin necrosis
8)Patient with cold related gelling or agglutination like in 1)cryoglobulinemia , monoclonal
2) cryofibrinogenemia 3) cold agglutinins
9)Patient with vessel â?? invasive fungi
10)Patient with ecthyma gangrenosum
• Patient with disseminated strongyloidiasis
12)Patient with Protein C and S related 1) Homozygus protein C or protein S deficiency 2)
Acquired protein C deficiency 3) Coumadin /Warfarin necrosis (protein C dysfunction) 4)
post infectious purpura fulminans (protein S dysfunction)
13) Patient with antiphospholipid antibody,lupus anticoagulant
• Patient with Sneddon syndrome (vascular coagulopathy)
15)Patient with embolization or crystal deposition like 1) cholesterol emboli 2) oxalate
crystal deposition 3) marantic endocarditis, atrial myxoma, crystal globulins,
hypereosinophilic syndrome
16)Patient with high reticulocyte states like sickle cell disease, other severe hemolytic
anemias, severe malaria
17)Patient with cutaneous calciphylaxis, Brown recluse spider bite reaction , Intravascular
B cell lymphoma
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method