CTRI/2020/01/022981Not yet recruiting未知
Study of cutaneous vasculitis, vascular coagulopathies and their clinico-pathological correlation
GCS Medical College Hospital and Research Centre0 sites0 target enrollmentStarted: TBDLast updated:
Trial Snapshot
- Phase
- 未知
- Status
- Not yet recruiting
- Sponsor
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
Inclusion Criteria
- •Patients of either sex and of all age group.
- •Patient presenting clinical sign and symptoms suggestive of cutaneous vasculitis or
- •vasculopathy like,
- •1) Palpable purpura
- •2) Petechiae
- •3) Macular purpura
- •4)Urticarial papules
- •5) Vesicles
- •6)Pustules
- •7)Targeted papules and plaques
- •8) Livedo racemosa
- •9)Retiform purpura
- •11)Subcutaneous nodules
- •12)Digital necrosis
- •13)Erythema
- •14)Cyanotic skin
- •15)Livedo reticularis
- •16)Atrophie blanche
- •17)Ecchymotic streak
- •18)Any other on PI discretion.
Exclusion Criteria
- •1)All patient not willing to give consent
- •2)Any systemic vascultis case without cutaneous manifestations.
- •Patients having pre-existing or detected during study work up any other disease which
- •mimic cutaneous vasculitis and diseases involving vessel walls other than livido
- •vasculopathy and malignant atrophic papulosis will be excluded from final analysis.
- •Following is list of such disorders.( this is not definite list any other compounding
- •factor on PI discretion will be excluded from final analysis.)
- •3)Patient with hemostatically relevant thrombocytopenia (<50,000/cu mm) in following
- •Idiopathic thrombocytopenic purpura
- •Thrombotic thrombocytopenic purpura
- •Disseminated intravascular coagulation
- •Thrombocytopenia due to 1) drug related peripheral destruction (eg quinine, quinidine)
- •2) Drug induced decreased production, idiosyncratic or dose related (eg chemotherapy) 3)
- •Bone marrow infiltration, fibrosis or failure
- •4) Patient with congenital or hereditary platelet function defects
- •5)Patient with acquired platelet function defects due to 1) Aspirin, NSAIDs 2) Renal
- •insufficiency 3) Monoclonal gammopathy
- •6)Patient with thrombocytosis secondary to myeloproliferative disorders (often >1000000/cu
- •7)Patient with occlusion primarily due to microvascular platelet plugs like heparin necrosis
- •8)Patient with cold related gelling or agglutination like in 1)cryoglobulinemia , monoclonal
- •2) cryofibrinogenemia 3) cold agglutinins
- •9)Patient with vessel â?? invasive fungi
- •10)Patient with ecthyma gangrenosum
- •Patient with disseminated strongyloidiasis
- •12)Patient with Protein C and S related 1) Homozygus protein C or protein S deficiency 2)
- •Acquired protein C deficiency 3) Coumadin /Warfarin necrosis (protein C dysfunction) 4)
- •post infectious purpura fulminans (protein S dysfunction)
- •13) Patient with antiphospholipid antibody,lupus anticoagulant
- •Patient with Sneddon syndrome (vascular coagulopathy)
- •15)Patient with embolization or crystal deposition like 1) cholesterol emboli 2) oxalate
- •crystal deposition 3) marantic endocarditis, atrial myxoma, crystal globulins,
- •hypereosinophilic syndrome
- •16)Patient with high reticulocyte states like sickle cell disease, other severe hemolytic
- •anemias, severe malaria
- •17)Patient with cutaneous calciphylaxis, Brown recluse spider bite reaction , Intravascular
- •B cell lymphoma
Investigators
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