Contemporary Management And Outcomes In Patients With Asymptomatic Deep Vein Thrombosis Registry
- Conditions
- Deep Vein Thrombosis
- Registration Number
- JPRN-UMIN000021497
- Lead Sponsor
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Brief Summary
The subjects had concomitant active cancer in 40%, unprovoked DVT in 59%, and distal DVT in 70%. The cumulative 5-year incidences of symptomatic recurrent venous thromboembolism (VTE); major bleeding; and all-cause death were 14.5%, 16.6%, and 34.1%, respectively. Among 232 patients (77%) with prolonged anticoagulant therapy, anticoagulants were discontinued in 48.4% at 1 year. Anticoagulant therapy was associated with a significantly higher incidence of major bleeding compared with the non-anticoagulant group (20.5% vs. 1.5%, P=0.01) with no significant effect on the incidence of VTE. In patients with active cancer, the favorable effect of anticoagulants relative to no anticoagulants for VTE was significant (HR, 0.22; 95% CI: 0.05-0.95).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 300
Not provided
Patients with symptomatic pulmonary embolism.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause death, Recurrence of symptomatic VTE, Bleeding event
- Secondary Outcome Measures
Name Time Method Acute myocardial infarction, Stroke, Invasive treatment, Postthrombotic syndrome