NCT02572778招募中不适用
Establishment of Primary Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer for Preclinical Evaluation of Targeted Therapies.
Cliniques universitaires Saint-Luc- Université Catholique de Louvain1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2015年9月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Identification of the biomarkers of new cancer therapies for head and neck cancer on the patient-derived xenografts with immunohistochemistry (KI67) on FFPE (fixation followed by paraffin embedding) slides
研究概览
简要总结
The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to:
generate a biobank of in vivo patient xenografts representing the different subgroups of tumors for head and neck cancer
- perform genetic and transcriptional profiling of the primary, metastatic tumors and xenograft tumors
- evaluate the efficacy of new targeted agents, whether or not in combination with standard treatment options
- evaluate biomarkers of drug sensitivity
- study primary and secondary (acquired) resistance in these models
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In the first phase, all patients with primary or recurrent/ metastatic disease of head and neck cancer can be included pre-operatively or before a tumor biopsy after obtaining informed consent
- •Data on stage, grade, histology, adjuvant treatment, responses, relapse should be available
- •Follow-up data should be available
- •Patients with recurrent disease are allowed
- •Written informed consent
排除标准
- 未提供
结局指标
主要结局
Identification of the biomarkers of new cancer therapies for head and neck cancer on the patient-derived xenografts with immunohistochemistry (KI67) on FFPE (fixation followed by paraffin embedding) slides
时间窗: 10 years
Identification of the biomarkers of new cancer therapies for head and neck
次要结局
- Characterization of the biomarkers of new cancer therapies for head and neck cancer on the patient-derived xenografts with genetic techniques(10 years)
研究者
研究点 (1)
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