Synergistic effect of Clonidine on sedation requirements in Paediatric Intensive Care (PICU)

Phase 4

• Conditions: sedation in critical illness; Anaesthesiology - Other anaesthesiology; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12610000079044
• Lead Sponsor: Alana Kirkwood

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-01-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

patients admitted to PICU during study enrollment period, expected to be ventilated for greater than 24 hours

Exclusion Criteria

1. Ventilated less than 24 hours
2. Pre or post-op condition or morbidity precludes the use of the study drug.
3. Hypotension
4. Status Epilepticus
5. Non-pharmacological Coma/ encephalopathy
6. Renal Failure defined as
(a)Creatinine Clearance (CrCl)<10ml/min
(b)requiring Renal Replacement
Therapy (RRT)
(c) End Stage Renal Failure (ESRF)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall daily consumption of morphine and midazolam (mcg/kg/day) <br><br>This is documented as hourly and daily totals in digital nursing records[per day, for duration of PICU stay];overall sedation score by assessment of the State Behavioural Score (SBS).[for duration of PICU stay <br><br>This outcome is documented as daily running total in digital records.]

Secondary Outcome Measures

Name	Time	Method
length of stay (days)[for duration of PICU stay];ventilator hours[for duration of PICU stay]