jRCTs061180062已完成不适用
The efficacy of reduced form of coenzyme Q10 in the Treatment of dementia (The efficacy of reduced form of coenzyme Q10 in the Treatment of dementia)
未提供0 个研究点目标入组 100 人开始时间: 2017年2月13日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- Frequency of participants with change of ADAS-Jcog being less than zero
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized Controlled Trial
- 干预模型
- Parallel Assignment
- 主要目的
- Prevention Purpose
- 盲法
- Double Blind
入排标准
- 年龄范围
- 50age old over 至 89age old under（—）
- 性别
- All
入选标准
- •Diagnosis is one of five types of dementia.
- •Alzheimer disease, Vascular dementia, Dementia of Lewy Body, frontotemporal dementia, Mild Cognitive Impairment: (MCI)
- •Clinical Dementia Rating (CDR) is 0.5,1 or 2 (mild-moderate dementia).
- •Mini-Mental State Examination (MMSE) score is between 15 and
- •Treatment has been kept with four drugs, donepezil, galantamine, rivastigmine, memantine and some other drug.
- •Agreement with clinical trial is between 50 and 89 years old.
- •A declaration of consent shall be valid if drawn up as a document providing sufficient evidence.
排除标准
- •Metabolic encephalopathy (hypothyroidism, Vitamin B12 deficiency)
- •Post head trauma
- •Delirium due to any drugs
- •Alcohol abuse
- •Depression under medication
- •Mental disorder treated by antipsychotic drugs
- •Schizophrenia, mania, severe heart failure, and severe liver injury.
- •Chronic renal failure with creatinine clearance less than 20 ml/min.
- •Treated with malignancy
- •Investigator decides inappropriate for enrollment
结局指标
主要结局
Frequency of participants with change of ADAS-Jcog being less than zero
时间窗: 48 weeks
Frequency of participants with change of ADAS-Jcog being less than zero after dose of reduced Coenzyme Q10
次要结局
未报告次要终点
研究者
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