Perioperative ischemic evaluation study (POISE study)

McMaster University (Canada)0 个研究点目标入组 10,000 人开始时间: 2005年8月19日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Greater than or equal to 45 years of age, either sex
•2. Have an expected length of stay greater than or equal to 24 hours
•3. Fulfill any one of the following six criteria:
•3.1. Coronary artery disease
•3.2. Peripheral vascular disease
•3.3. History of stroke due to atherothrombotic disease
•3.4. Hospitalisation for congestive heart failure within 3 years of randomisation
•3.5. Undergoing major vascular surgery
•3.6. Any three of the following seven criteria: scheduled for high risk surgery (i.e. intraperitoneal or intrathoracic), emergency/urgent surgery, any history of congestive heart failure, history of a transient ischaemic attack (TIA), diabetes and currently on an oral hypoglycaemic agent or insulin therapy, preoperative serum creatinine greater than 175 µmol/l (greater than 2.0 mg/dl), or age greater than 70 years
•4. Are able to give written consent

•1. Contradiction to metoprolol including any of the following: significant bradycardia (heart rate less than 50 beats per minute); second or third degree heart block without a pacemaker, asthma that has been active within the last decade, and history of chronic obstructive pulmonary disease (COPD) with bronchospasm on pulmonary function tests
•2. Clinical plan to use a beta-blocker preoperatively or during the first 30 postoperative days
•prior adverse reaction to a beta-blocker
•3. Coronary artery bypass graft (CABG) surgery with complete revascularisation in the preceding 5 years and no evidence of cardiac ischaemia since the CABG surgery
•4. Patients undergoing low risk surgical procedures (potential examples include transurethral procedures [transurethral prostatectomies {TURPs}, stone baskets etc.], ophthalmologic procedures under topical or regional anaesthesia [cornea transplants, cataract surgery etc.], and surgeries with limited physiological stresses [digital re-implantation, nerve repairs etc.])
•5. Concurrent use of verapamil
•6. Prior enrolment in this trial

发起方

McMaster University (Canada)