NCT05714813已完成不适用
Circuit Resistance Training and Retinal Vascular Changes in Older Persons
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 3
- 主要终点
- Change in retinal vessel density as measured by Optical Coherence Tomography Angiography (OCTA)
研究概览
简要总结
The purpose of this research study is to see if high-speed weight training performed in a circuit (using one machine after another) can improve participant heart and brain function, strength, and power in older persons.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •65-90 years of age;
- •Montreal Cognitive Assessment (MoCA) > 23
- •no memory loss complaints
排除标准
- •Uncontrolled cardiovascular or neuromuscular diseases that prevent participation in a training program;
- •Cerebrovascular disease;
- •Malignancy within the previous 5 years;
- •Documented HIV infection or other immunodeficiency syndrome;
- •Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, or other serious concomitant medical illness;
- •A history of ocular surgeries (except for cataract surgery more than 6 months ago) or other ocular diseases;
- •Bilateral moderate or severe cataracts;
- •Refractive errors of myopia, hyperopia and/or astigmatism more than 6.0 Diopters.
结局指标
主要结局
Change in retinal vessel density as measured by Optical Coherence Tomography Angiography (OCTA)
时间窗: Baseline, 24 weeks
OCTA uses a special camera system and software to measure the densities of the small vessels (microvasculature) of the retinal layers of the eye.
次要结局
- Change in Event Memory as measured by the Picture Sequence Memory Test(Baseline, 24 weeks)
- Change in Information Sorting as measured by the NIH List Sorting Test(Baseline, 24 weeks)
- Change in Reaction Time for a Mental Task as measured by the NIH Pattern Comparison Processing Speed Test(Baseline, 24 weeks)
- Change in Dynamic Balance as measured by the Timed Up-and-Go test(Baseline, 24 weeks)
- Change in the Ability to perform Daily Activities as measured by the Physical Performance Test(Baseline, 24 weeks)
- Change in cardiovascular fitness as measured by the Six-minute walk test.(Baseline, 24 weeks)
- Change in neuromuscular performance as measured by 1-repetition maximum (1RM)(Baseline, 24 weeks)
- Change in Recall and Recognition as measured by the Hopkins Verbal Learning Test(Baseline, 24 weeks)
- Change in Dual Tasking ability as measured by the Trail Making Test(Baseline, 24 weeks)
- Change in Concept Switching as measured by the Dimensional Card Sort test.(Baseline, 24 weeks)
- Change in Congruent and Incongruent Responses as measured by the Flanker test(Baseline, 24 weeks)
- Change in neuromuscular performance as measured by power production.(Baseline, 24 weeks)
研究者
Joseph Signorile
Professor
University of Miami
研究点 (3)
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