Improving Food Pleasure and Intake of Oncology Patients Receiving Chemotherapy
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- change of taste chemotherapy-related alterations
研究概览
简要总结
The global cancer burden is estimated to have risen to 18.1 million new cases in 2018 (WHO), with a trend of ongoing growth. This very frequent illness exerts tremendous physical, emotional and financial strain on individuals, families, communities and health systems.
Malnutrition (under- or over-nutrition) is highly prevalent in cancer patients receiving chemotherapy and is an important predictor of morbidity, mortality, treatment response and toxicity. Alterations in taste and smell are frequently reported as side effect of chemotherapy and may contribute strongly to malnutrition and to a worsen quality of life and wellbeing social, emotional, and role functioning. There are evidences that chemotherapy influences food liking and appetite with implications for food behaviours, including food enjoyment, food preference and dietary intake. A linkage between alterations in taste and /or smell and food behaviours has been reported by some studies but not all, suggesting that there is a need for more research using common standardised methodologies and larger sample size to gain a further insight into this topic.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pathological diagnosis of colorectal or breast cacer
- •indication to adjuvant chemotherapy for colon cancer according local guide lines
- •indication to (neo)-adjuvant chemotherapy for reast cancer according local guide lines
- •possiility to sign an informed consent
排除标准
- •patients aged <18 years
- •patients aged >80 years
研究组 & 干预措施
patients with colon cancer
干预措施: Chemotherapy (Drug)
patients with breast cancer
干预措施: Chemotherapy (Drug)
结局指标
主要结局
change of taste chemotherapy-related alterations
时间窗: the variables will be measured at four time points: before chemotherapy (T0), after 4 cycles (T1, each cycle is 21 days), at the end of chemotherapy (T2, 6 months from T0) and three months after the conclusion of the therapy (T3, 9 months from T0)
To better understand alteration of taste/smell and food behaviours by the self-report responses, using an adapted version of a questionnaire set up to measure taste changes due to COVID-19
次要结局
- Emotions elicited by foods(the variables will be measured at four time points: before chemotherapy (T0), after 4 cycles (T1, each cycle is 21 days), at the end of chemotherapy (T2, 6 months from T0) and three months after the conclusion of the therapy (T3, 9 months from T0))
研究者
Giandomenico Roviello
Assistant professor, md, phd
University of Florence