MedPath

Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy

Not Applicable
Conditions
Stomach Neoplasms
Registration Number
NCT02837874
Lead Sponsor
Keimyung University Dongsan Medical Center
Brief Summary

Billroth-II (gastrojejunostomy) is one of major option after gastrectomy for gastric cancer. The investigators hypothesized that isoperistaltic anastomosis lead to higher incidence of dumping syndrome but antiperistaltic (anisoperistaltic) anastomosis have relevance to gastric stasis or obstruction. The investigators will assess complications, dumping syndrome and quality of life between isoperistaltic and antiperistaltic after distal gastrectomy for gastric cancer.

Detailed Description

Recently, laparoscopic approach has been a option for gastric cancer, especially early gastric cancer. There are growing interest in quality of life in addition to recurrence or survival. There are few report about peristalsis and no report for quality of life according to a direction of peristalsis.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
80
Inclusion Criteria
  • Histologically confirmed adenocarcinoma in stomach
  • Scheduled as laparoscopic distal gastrectomy (tumor located lower or middle third)
  • Planned with gastrojejunostomy after gastrectomy
  • Clinical stage T1N0M0 or T2N0M0
  • ECOG 0 or 1 (The Eastern Cooperative Oncology Group)
  • ASA score class I-III (The American Society of Anesthesiologists)
  • patient has given their written informed consent to participate in the study
Exclusion Criteria
  • Simultaneously combined resection of other organ (including cholecystectomy)
  • Active other malignancy
  • Requiring total gastrectomy
  • Chronic inflammatory bowel disease or other chronic disease related to bowel motility
  • Uncontrolled diabetes or patients with diabetic complications
  • Vulnerable patients

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Dumping syndrome12 months

Using Sigstad's score

Secondary Outcome Measures
NameTimeMethod
long-term complicationfrom 1 month to 12 months

all kind of complication

Total score of quality of life questionnaire12 months

by EORTC questionnaire

Body weight change12 months

for evaluate nutritional status

Surgical complicationwithin 1 month

all kind of complication within 1 month

Gastritis12 months

by endoscopic evaluation

Trial Locations

Locations (1)

Keimyung University Dongsan Medical Center

🇰🇷

Daegu, Korea, Republic of

Keimyung University Dongsan Medical Center
🇰🇷Daegu, Korea, Republic of
Seung Wan Ryu, MD, PhD
Principal Investigator
In Gyu Kwon, MD
Sub Investigator
Young Gil Son, MD, PhD
Sub Investigator

MedPath

Empowering clinical research with data-driven insights and AI-powered tools.

© 2025 MedPath, Inc. All rights reserved.