Analgesic Efficacy of Adding Dexmedetomidine VS Magnesium Sulphate as Adjuvants With Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Post Thoracotomy Pain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Total postoperative morphine consumption
研究概览
简要总结
Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Care Provider, Investigator)
盲法说明
Double blinded
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 65 years.
- •Male and female sexes.
- •ASA I-II.,III
- •Cancer patients undergoing thoracotomy incisions
- •Body mass index (BMI) from 18.5 to 30 kg/m2
排除标准
- •Patient refusal
- •Known allergy to any of the used drugs
- •Low platelet count, any coagulation defect
研究组 & 干预措施
Erector spinae plane block with 0.25% bupivacaine
Patients will receive ultrasound guided ESPB with 0.25% bupivacaine
干预措施: Bupivacaine (Drug)
Erector spinae plane block with 0.25% bupivacaine and Magnesium
Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and magnesium
干预措施: Bupivacaine + Magnesium (Drug)
Erector spinae plane block with 0.25% bupivacaine and Dexmedetomidine
Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and dexmedetomidine
干预措施: Bupivacaine + Dexmedetomidine (Drug)
结局指标
主要结局
Total postoperative morphine consumption
时间窗: First 24 hours postoperatively
Total dose of morphine needed postoperatively in the first 24 h
次要结局
- Time to first postoperative rescue analgesia.(First 24 hours postoperatively)
研究者
Walaa Youssef Elsabeeny
Assistant professor of Anesthesia and Pain management
National Cancer Institute, Egypt