Oocyte vitrification in women at risk of ovarian failure; an observational study with follow-up of childre

Withdrawn

• Conditions: birth defect; congenital malformations; 10027664; 10038612

• Registration Number: NL-OMON34190
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 1321

Inclusion Criteria

1. Women until their 40th birthday who are at risk of ovarian failure due to iatrogenic gonadotoxic treatment.
2. Women until their 40th birthday who are at risk of premature ovarian failure and women between the ages of 30th and 40th birthday who are at risk of ovarian failure due to increasing age.
3. Women until their 43rd birthday undergoing an IVF/ICSI cycle during which no spermatozoa can be obtained at the time of follicle aspiration.

Exclusion Criteria

1. Women with borderline or invasive ovarian cancer.
2. Women with contraindications for IVF treatment such as cardiovascular-pulmonary disease, severe diabetes, bleeding disorders, immunodeficiency, morbid obesity, and premature ovarian failure.
3. Women with severe psychopathology, severe anxiety and inability to cope.
4. Women who reach, at the time they request thawing of their oocyte, the maximum age at which embryo transfer is accepted by Dutch guidelines (currently from their 45th birthday).
5. Not able or willing to provide informed consent.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome is the number of congenital abnormalities in babies born after<br /><br>oocyte vitrification (%).</p><br>