Third Trimester Routine Ultrasound in Low-risk Pregnancies : Comparison of Two Timing Periods Procedure for Screening Intrauterine Growth Restriction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Fetal Growth Retardation
- Sponsor
- University Hospital, Rouen
- Enrollment
- 3760
- Locations
- 1
- Primary Endpoint
- Number of small for gestational age infant screened by a routine ultrasound in the third trimester (sensitivity).
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Late intrauterine growth restriction is infrequently diagnosed with an overall sensitivity of 40 % in low-risk pregnancies. In addition, late intrauterine growth restriction may be associated with intrauterine death and poor neonatal outcomes i.e. birth asphyxia and hospitalization in intensive care unit. The investigators hypothesis that a later third trimester routine ultrasound may be more accurate to diagnose late intrauterine growth restriction.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Accurate gestational dating using crown-rump length at 11-14 weeks
- •Singleton pregnancy
- •Primiparity
- •Normal First trimester (11-14 weeks) and second trimester (20-25 weeks) scans
- •Maternal age \> 18 years
- •No maternal opposition for the study
Exclusion Criteria
- •Maternal diseases i.e. chronic renal disease, hypertension, diabetes, collagen vascular disease, antiphospholipid syndrome
- •Pregnancies with congenital anomalies or foetal growth restriction diagnosed before 30 weeks of gestation
Outcomes
Primary Outcomes
Number of small for gestational age infant screened by a routine ultrasound in the third trimester (sensitivity).
Time Frame: At birth
SGA infant and intrauterine growth restriction are defined using a threshold below the tenth percentile for customized birth weight or customized estimated birth weight.
Secondary Outcomes
- Number of neonate with a customized birth weight upper the tenth percentile adequately screened by a routine ultrasound in the third trimester (specificity).(At birth)
- Number of prenatal consultations, ultrasound scans performed, maternal hospitalization, labor induction, and caesarean section induced by the third trimester routine ultrasound(After the delivery)
- Maternal complications and neonatal outcomes.(In the postpartum period)