Defining Beef and Meal Frequency as Key Components of a Healthy Eating Pattern for Muscle Health and Wellbeing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Compare fractional synthesis rate of myofibrillar proteins to different dietary protein food sources and meal frequencies
研究概览
简要总结
Adopting a healthy eating pattern is important for meeting dietary recommendations and weight management. Although less clear, it seems reasonable to assume that the eating patterns we typically follow can also affect our psychological wellbeing. As such, healthy eating patterns are often adapted to suit one's personal preference. For example, many people choose to follow a vegetarian-style eating pattern whereby meat, poultry, and seafood are excluded from the diet. However, current research suggests that vegetarian eating patterns may result in decreased synthesis of new muscle proteins when compared to the typical meat-based US-style diet. This ultimately leads to reduced muscle quality and mass which increases the risk of dependence and mobility limitations later in life.
Another important factor to consider when adapting a healthy eating pattern is the frequency and distribution of meals throughout the day. In the US, protein intake is typically skewed throughout the day such that people consume more protein at dinner when compared to breakfast. This skewed distribution combined with a low meal frequency (3 meals per day) can also sacrifice the rate of muscle protein synthesis. As such, it is important to investigate the interaction between food choices, meal frequency, and protein distribution to promote muscle health and prevent development of disease and disability. In addition, it is also important to understand how these eating patterns affect enjoyment and pleasure following meals. This work will help to determine healthy eating patterns that promote muscle health and psychological wellbeing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 20-40
- •Pre-menopausal
- •Recreationally active
- •Weight stable for prior 6 months
- •Consumption of meat-based diet for >6 months
排除标准
- •Age outside of range (20 - 40)
- •Pregnancy
- •Irregular menstrual cycles
- •Participation in previous research using 2H2O or [13C6]phenylalanine
- •Participation in other ongoing research that interferes with this study (e.g., conflicting diet, activity interventions, etc.)
- •Any hospitalization or surgery for a metabolic, cardiovascular, or neuromusculoskeletal complication within the past year
- •Allergy or hypersensitivity to local anesthetics, latex, or adhesives (bandages, medical tape, etc.)
- •Excess scarring after injury
- •History of excess bleeding after cut
- •Chronic or frequent dizziness/fainting, and arm or leg weakness/numbness
- •Arthritis
- •Mental Illness
- •Hepatorenal, cardiovascular musculoskeletal, autoimmune, or neurological disease or disorder
- •Predisposition to hypertrophic scarring or keloid formation
- •Physical activity limitations
- •Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation
- •Consumption of thyroid, androgenic, or other medications known to affect endocrine function
- •Consumption of medications known to affect protein metabolism (e.g., prescription-strength corticosteroids, nonsteroidal anti-inflammatories, or acne medication)
- •Unwillingness to comply with study procedures
- •Weight unstable (variation >5% of bodyweight in last 6-12 months)
- •Pregnancy
- •Allergy to dairy product or lactose intolerance
- •Current or previous tobacco use with last 6 months
- •Obesity (body mass index; BMI > 30 kg m-2)
- •Score of less than 14 or greater than 24 on Godin-Shephard Leisure-Time Physical Activity Questionnaire
研究组 & 干预措施
Animal Protein - Skewed Distribution
Animal-based protein foods with 3 meals per day consisting of 10-, 30-, and 60% of dietary protein for breakfast, lunch, and dinner, respectively.
干预措施: Animal-based Protein Foods (Behavioral)
Animal Protein - Skewed Distribution
Animal-based protein foods with 3 meals per day consisting of 10-, 30-, and 60% of dietary protein for breakfast, lunch, and dinner, respectively.
干预措施: Skewed Protein Distribution (Behavioral)
Plant Protein - Skewed Distribution
Plant-based protein foods with 3 meals per day consisting of 10-, 30-, and 60% of dietary protein for breakfast, lunch, and dinner, respectively.
干预措施: Skewed Protein Distribution (Behavioral)
Plant Protein - Skewed Distribution
Plant-based protein foods with 3 meals per day consisting of 10-, 30-, and 60% of dietary protein for breakfast, lunch, and dinner, respectively.
干预措施: Plant-based Protein Foods (Behavioral)
Animal Protein - Balanced Distribution
Animal-based protein foods with 5 meals per day consisting of 20% of dietary protein per meal.
干预措施: Animal-based Protein Foods (Behavioral)
Animal Protein - Balanced Distribution
Animal-based protein foods with 5 meals per day consisting of 20% of dietary protein per meal.
干预措施: Balanced Protein Distribution (Behavioral)
Plant Protein - Balanced Distribution
Plant-based protein foods with 5 meals per day consisting of 20% of dietary protein per meal.
干预措施: Plant-based Protein Foods (Behavioral)
Plant Protein - Balanced Distribution
Plant-based protein foods with 5 meals per day consisting of 20% of dietary protein per meal.
干预措施: Balanced Protein Distribution (Behavioral)
结局指标
主要结局
Compare fractional synthesis rate of myofibrillar proteins to different dietary protein food sources and meal frequencies
时间窗: Day 1 - Day 9
Rate of building new protein in skeletal muscle contractile protein
Compare fractional synthesis rate of myofibrillar proteins to different dietary protein food sources and meal frequencies
时间窗: Day 1 - Day 9
Rate of building new protein in skeletal muscle contractile protein
次要结局
- Valence (Pleasantness or Unpleasantness)(Immediately prior to workout, immediately post workout, and immediately post meal on habituation days 2, 4, and 6 and intervention days 3, 5, and 7)
- Arousal (Alertness)(Immediately prior to workout, immediately post workout, and immediately post meal on habituation days 2, 4, and 6 and intervention days 3, 5, and 7)
- Valence (Pleasantness or Unpleasantness)(Immediately prior to workout, immediately post workout, and immediately post meal on habituation days 2, 4, and 6 and intervention days 3, 5, and 7)
- Arousal (Alertness)(Immediately prior to workout, immediately post workout, and immediately post meal on habituation days 2, 4, and 6 and intervention days 3, 5, and 7)
