UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 23,826
- 试验地点
- 1
- 主要终点
- To find genes which predispose to PrCa
研究概览
简要总结
The UKGPCS was set up to find genetic alterations which occur in patients who have prostate cancer.
A man's risk of developing prostate cancer increases if he has a first-degree relative (father or brother) who was diagnosed with prostate cancer at a young age. This is why we are looking for men who are affected at a young age or who have a family history of prostate cancer, since it is more probable that these prostate cancers are due to an inherited genetic cause rather than an environmental cause.
We also ask all men who come to the Royal Marsden Hospital to be treated for prostate cancer if they would like to take part in the study so that we can also look to see if we find genetic alterations in older men, and those who do not have a family history of prostate cancer.
详细描述
The study is divided into two parts:
- The Study at The Royal Marsden NHS Foundation Trust, London and Sutton:
The study will be offered to every patient attending the prostate clinics at The Royal Marsden NHS Foundation Trust, London and Sutton. This is called 'The Systematic Study'.
Patients are approached in the clinic and are given an information sheet and the study is also explained verbally. They are asked for 18ml of blood and asked to fill out a family history and epidemiological questionnaire. Those who have not had any treatment will also be asked for 18ml blood for serum and plasma marker studies.
Those patients with one relative affected with PrCa where one is ≤ 65 years at diagnosis or a total of 3 or more relatives with PrCa at any age, will be asked if their relatives can be approached to be asked to give a blood sample for DNA analysis for PrCa predisposition genes and tumour samples for molecular analyses for PrCa predisposition and behaviour as outlined above. Where relatives with PrCa are deceased, pathology records and tumour blocks will be requested after obtaining details of where they were treated via the index case.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Man with PrCa at any age at diagnosis at Royal Marsden NHS Foundation Trust
- •Those outside the Royal Marsden NHS Foundation Trust with
- •PrCa at or below 60 years at diagnosis
- •PrCa in first-degree related pairs where one is ≤ 65 years at diagnosis
- •PrCa at any age in a cluster with 3 or more cases
- •Those able to understand the information sheet and give informed consent (language line is available for those who wish to have translation)
- •Any unaffected relatives of men who are already taking part in the study
排除标准
- •Man with PrCa who is too ill to take part
结局指标
主要结局
To find genes which predispose to PrCa
时间窗: 2017
次要结局
未报告次要终点