GRACE (Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe). Workpackage 10: Antibiotic trial one. - GRACE AT ONE

niversity of Southampton0 个研究点目标入组 3,000 人开始时间: 2007年9月7日最近更新: 2020年10月6日

适应症

试验速览

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•Eligible patients will be:
•- Aged 18 to 59 and 60 years and over (enrolment will be done in such way that 1500 patients under 60 and 1500 patients of 60 years and older)
•- Consulting with acute cough as the main symptom (up to 28 days duration) or those in whom the general practitionor suspects the presence of acute LRTI
•- Immunocompetent
•-Consulting for the first time within this illness episode
•-Able to fill out study material
•- Who have provided written informed consent to participate
•-Who have not been included earlier in the current GRACE trial, either as a case or control
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Patients who have had antibiotics in the previous month, patients who are unable to properly consent or fill out the diary (dementia, psychosis, depression), patients who are pregnant, patients who are allergic to penicillin, and those with history/physical examination suggestive of community-acquired pneumonia - on ethical grounds, GPs would be very unlikely to be willing to randomise patients with pneumonia.

发起方

niversity of Southampton