Kaempferol Gel , Alkaline Phosphatase Activity , Bone Density Around Dental Implants
- Conditions
- Peri-implant Bone Healing and Osseointegration
- Interventions
- Drug: Kaempferol Gel
- Registration Number
- NCT07156799
- Lead Sponsor
- Al-Azhar University
- Brief Summary
Kaempferol gel was tested as a local adjunct during implant placement in 30 patients. Compared to controls, the Kaempferol group showed significantly higher ALP activity at 2 and 4 weeks and greater bone density gain after 6 months (40.73% vs. 33.21%). These findings suggest Kaempferol enhances early bone remodeling, improves peri-implant bone quality, and may allow earlier implant loading.
- Detailed Description
This randomized controlled clinical trial investigated the effect of Kaempferol gel, a natural antioxidant and bone-healing compound, on dental implant healing in the maxillary posterior region. Thirty patients were divided into two groups: one received Kaempferol gel during implant placement, while the other did not.
The study measured alkaline phosphatase (ALP) activity in peri-implant crevicular fluid at 1, 2, and 4 weeks, and bone density using CBCT at baseline and 6 months. Results showed that Kaempferol significantly boosted ALP activity at 2 and 4 weeks, suggesting faster bone remodeling. At 6 months, bone density improved in both groups, but the Kaempferol group showed a greater increase (40.73% vs. 33.21%).
In conclusion, Kaempferol gel enhanced early bone healing and improved bone density around implants, indicating its potential as a cost-effective, biocompatible adjunct to accelerate osseointegration and possibly allow earlier implant loading, particularly in patients with poor bone quality.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- At least one missing maxillary posterior tooth with a healed ridge
- Previous bone grafting at the implant site.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description test group Kaempferol Gel kaempferol gel application and implant placement
- Primary Outcome Measures
Name Time Method alkaline phosphatase level at baseline, 1,2, 4 weeks Change in alkaline phosphatase (ALP) activity measured in peri-implant crevicular fluid (PICF) using ELISA to evaluate early bone remodeling activity.
- Secondary Outcome Measures
Name Time Method Bone density around implants Baseline and 6 months postoperatively Change in peri-implant bone density assessed by cone beam computed tomography (CBCT) at the implant site
Trial Locations
- Locations (1)
Faculty of Dental Medicine for Girls, Al-Azhar University
🇪🇬Cairo, Cairo Governorate, Egypt
Faculty of Dental Medicine for Girls, Al-Azhar University🇪🇬Cairo, Cairo Governorate, Egypt