Neural Mechanisms by Which Chronic Stress Regulates Inflammation in Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Neural activity in response to stress
研究概览
简要总结
Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing substantial impairment that is reflected in the tens of millions of missed days of work, and doctors' and emergency room visits it leads to annually. Those who have asthma are twice as likely to develop depression and anxiety, which are associated with more frequent and severe asthma symptoms, especially in those under chronic stress. The project proposed here seeks to understand the role of the brain in these associations and to evaluate the neural mechanisms through which a safe, low-cost intervention, that influences the function of body via the mind, may diminish the expression of asthma symptoms.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Asthmatics:
- •Physician diagnosed asthma with previous use of asthma medication
- •Controls:
- •negative skin-prick test to cat dander or house dust mite and have no history of asthma
- •Chronic Stress:
- •score 3 or above on any subscale of the UCLA (University of California Los Angeles) chronic stress interview
- •No chronic stress:
- •score 1.5 or below on all subscales of the UCLA chronic stress interview
排除标准
- •Individuals with severe asthma, or those whom currently require the use of corticosteroids
- •Individuals with significant medical problems
- •Individuals who smoke cigarettes
- •Individuals a previous adverse reaction to corticosteroids, a recent (< 1 month) viral illness, a history of severe asthma or anaphylaxis.
- •Breastfeeding women or women who are, suspect they might be or are trying to become pregnant
结局指标
主要结局
Neural activity in response to stress
时间窗: duration of stress (30 minutes)
positron emission tomography
inflammation
时间窗: 24 hours
infiltration of eosinophils into lung sputum, percentage of blood eosinophils, exhaled nitric oxide, glucocorticoid sensitivity of peripheral blood leukocytes
lung function
时间窗: 24 hours
peak expiratory volume in 1 sec effort
peripheral acute stress reactivity
时间窗: 60 minutes
salivary cortisol and alpha amylase in response to acute stressor
次要结局
未报告次要终点