Analysis of the Molecular Profile of the Mixofibrosarcoma of the Extremities
Completed
- Conditions
- Sarcoma,Soft Tissue
- Registration Number
- NCT04991883
- Lead Sponsor
- Istituto Ortopedico Rizzoli
- Brief Summary
Single institution case series review with a histological diagnosis of mixofibrosarcoma of the extremities from 01 Jan 1993 to 01 Dec 2017.
The study will exam all the clinical, radiological, histological and immunohistochemical features of this tumour in all samples and in a limited serie of cases the presence of mutation of 50 genes cancer related.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 167
Inclusion Criteria
- Male and female patients treated at Rizzoli Institute from 01 Jan 1993 to 01 Dec 2017
- Diagnosis of mixofibrosarcoma of extremities
- Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis and molecular analysis
- Enough tumor biobanked material available for molecular analysis
- Presence of the biobank signed informed consent
- Written informed consent prior to any study-specific analysis and/or data collection
Exclusion Criteria
- Patients with histological diagnosis different from mixofibrosarcoma of extremities
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method disease-free survival at baseline (Day0) identify patients with different risk classes in terms of disease-free survival (local and systemic recurrence).
overall survival at baseline (Day0) identify patients with different risk classes in terms of overall survival.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Istituto Ortopedico Rizzoli
🇮🇹Bologna, BO, Italy