JPRN-jRCT1031220344招募中4 期
Randomized, open-label, controlled study to evaluate the efficacy of angiotensin receptor neprilysin inhibitor in patients with aortic stenosis undergoing transcatheter aortic valve implantation.
Kitahara Hideki0 个研究点目标入组 84 人开始时间: 2022年9月22日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 84
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 70age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1) A patient with aortic stenosis and the symptoms of heart failure requiring transcatheter aortic valve implantation based on 2020 Guideline on the Management of Valvular Heart Disease.
- •2) A patient who is scheduled transcatheter aortic valve implantation at Chiba university hospital.
- •3) A patient aged 70 years or older at the time of enrollment.
- •4) A patient who has provided written informed consent to participate in this study (if the patient can not sign by oneself, it is acceptable that a family or a person following a family writes on behalf).
排除标准
- •1) Acute heart failure (NYHA class IV)
- •2) Systolic blood pressure <110 mmHg
- •3) Severe hepatic dysfunction (Child-Pugh class C)
- •4) Severe renal dysfunction (serum creatinine > 3.0mg/dL)
- •5) Hemodialysis
- •6) Hyperkalemia (serum K >5.5 mEq/L)
- •7) Bilateral renal artery stenosis
- •8) A history of angioedema
- •9) A patient with diabetes on Aliskiren fumarate
- •10) A patient without written informed consent
- •11) A patient whom the investigator considers to be ineligible as a subject
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