A Comparison of Effectiveness of Amitriptyline and Topiramate in the Treatment of Painful Diabetic Neuropathy
Not Applicable
Completed
- Conditions
- Diabetic neuropathy.Autonomic neuropathy in endocrine and metabolic diseases
- Registration Number
- IRCT201210113565N6
- Lead Sponsor
- Endocrine Research Centre of Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Inclusion criteria :patients with diabetes mellitus ; both genders ; between 18-80 years of age ; under anti hyperglycemic agents therapy ;with diabetic peripheral neuropathy syptoms in the form of pain and paresthesia in rest for at least 1 month. Exclusion criteria : persons with any important clinical disease; unstable clinical or psychologic disease ; other neurupathic causes ;renal dysfunction ;liver disease ; epilepsy ;psychiatric disease ;uncontroled HTN ;malignancy ;opiate addiction ;anti epileptic ,anti depressant , topical anti pain or opioid tretmant ;pregnant and lactating women ; need to change treatment.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Response to treatment. Timepoint: 3 month. Method of measurement: History and Physical Exam , EMG/NCV if needed.
- Secondary Outcome Measures
Name Time Method