LIdocaine veRsus Sufentanil Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass

Completed

• Conditions: Opioid Free Anaesthesia; Opioid Anaesthesia
• Interventions: Other: Data collection

• Registration Number: NCT05136794
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

Since the 90's the concept of morphine sparing and morphine free anaesthesia (OFA) has progressively developed in non-cardiac surgery. The principle is based on the fact that in a sleeping patient a sympathetic reaction marked by hemodynamic modifications does not translate into a painful phenomenon, that a painful phenomenon in a sleeping patient is not memorized, that hormonal stress, the sympathetic reaction and the inflammatory reaction can be controlled by other therapeutic classes than a morphine agent. This therapeutic management would avoid the side effects associated with the use of morphine. In this hypothesis, OFA is more and more practiced in various situations without the real impact in terms of clinical benefit being clearly demonstrated. In cardiac surgery, some centers practice OFA with various protocols.The purpose of this work is to retrospectively evaluate over a defined period the incidence of postoperative complications, length of stay in the ICU/hospital, and death rate between patients managed with/without OFA based on lidocaine.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-11-16
• Study First Submitted QC: 2021-11-16
• Study First Posted: 2021-11-29
• Study Start: 2021-12-01
• Primary Completion: 2022-01-15
• Study Completion: 2022-01-15
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-11
• Last Update Posted: 2022-03-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1772

Inclusion Criteria

age over 18 years Cardiac surgery with cardiopulmonary bypass performed between January 2019 and June 2021

Exclusion Criteria

LVAD Heart transplantation Incomplete data in relation to outcomes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Opioid free anaesthesia	Data collection	patient anesthtesized with lidocaine
Opioid anaesthesia	Data collection	patients anesthetized with sufentanil

Primary Outcome Measures

Name	Time	Method
ICU stays (days)	Day 30	Total stay in ICU in day

Secondary Outcome Measures

Name	Time	Method
Hospital stays (days)	Day 30	hospital stay
Complications	Day 30	cardiac, neurological, renal, respiratory, red blood transfusion

Trial Locations

Locations (1)

Chu Dijon Bourgogne; 🇫🇷 Dijon, France