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临床试验/NCT05136794
NCT05136794已完成不适用

Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypas

Centre Hospitalier Universitaire Dijon1 个研究点 分布在 1 个国家目标入组 1,772 人开始时间: 2021年12月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
1,772
试验地点
1
主要终点
ICU stays (days)

研究概览

简要总结

Since the 90's the concept of morphine sparing and morphine free anaesthesia (OFA) has progressively developed in non-cardiac surgery. The principle is based on the fact that in a sleeping patient a sympathetic reaction marked by hemodynamic modifications does not translate into a painful phenomenon, that a painful phenomenon in a sleeping patient is not memorized, that hormonal stress, the sympathetic reaction and the inflammatory reaction can be controlled by other therapeutic classes than a morphine agent. This therapeutic management would avoid the side effects associated with the use of morphine. In this hypothesis, OFA is more and more practiced in various situations without the real impact in terms of clinical benefit being clearly demonstrated. In cardiac surgery, some centers practice OFA with various protocols.The purpose of this work is to retrospectively evaluate over a defined period the incidence of postoperative complications, length of stay in the ICU/hospital, and death rate between patients managed with/without OFA based on lidocaine.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • age over 18 years Cardiac surgery with cardiopulmonary bypass performed between January 2019 and June 2021

排除标准

  • LVAD Heart transplantation Incomplete data in relation to outcomes

研究组 & 干预措施

Opioid free anaesthesia

patient anesthtesized with lidocaine

干预措施: Data collection (Other)

Opioid anaesthesia

patients anesthetized with sufentanil

干预措施: Data collection (Other)

结局指标

主要结局

ICU stays (days)

时间窗: Day 30

Total stay in ICU in day

次要结局

  • Hospital stays (days)(Day 30)
  • Complications(Day 30)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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