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Clinical Trials/NCT05136794
NCT05136794CompletedNot Applicable

Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypas

Centre Hospitalier Universitaire Dijon1 site in 1 country1,772 target enrollmentStarted: December 1, 2021Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
1,772
Locations
1
Primary Endpoint
ICU stays (days)

Study Overview

Brief Summary

Since the 90's the concept of morphine sparing and morphine free anaesthesia (OFA) has progressively developed in non-cardiac surgery. The principle is based on the fact that in a sleeping patient a sympathetic reaction marked by hemodynamic modifications does not translate into a painful phenomenon, that a painful phenomenon in a sleeping patient is not memorized, that hormonal stress, the sympathetic reaction and the inflammatory reaction can be controlled by other therapeutic classes than a morphine agent. This therapeutic management would avoid the side effects associated with the use of morphine. In this hypothesis, OFA is more and more practiced in various situations without the real impact in terms of clinical benefit being clearly demonstrated. In cardiac surgery, some centers practice OFA with various protocols.The purpose of this work is to retrospectively evaluate over a defined period the incidence of postoperative complications, length of stay in the ICU/hospital, and death rate between patients managed with/without OFA based on lidocaine.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • age over 18 years Cardiac surgery with cardiopulmonary bypass performed between January 2019 and June 2021

Exclusion Criteria

  • LVAD Heart transplantation Incomplete data in relation to outcomes

Arms & Interventions

Opioid free anaesthesia

patient anesthtesized with lidocaine

Intervention: Data collection (Other)

Opioid anaesthesia

patients anesthetized with sufentanil

Intervention: Data collection (Other)

Outcomes

Primary Outcomes

ICU stays (days)

Time Frame: Day 30

Total stay in ICU in day

Secondary Outcomes

  • Hospital stays (days)(Day 30)
  • Complications(Day 30)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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