Changes of Optical Quality During the Peak of the Covid-19 Pandemic

Completed

• Conditions: SARS-CoV-2; Corneal Wavefront Aberration

• Registration Number: NCT05882383
• Lead Sponsor: Tianjin Eye Hospital

Brief Summary

To explore whether cornea structure, and optical quality are affected by the covid-19 infection.

Detailed Description

Participants with healthy corneas admitted to Tianjin Eye Hospital from November 25 to January 20, 2022 were followed up . At the end of the follow-up, the investigators recorded in detail whether the patients had undergone real-time reverse transcriptase polymerase chain reaction (covid-19 RT-PCR tests) testing, testing time and results. The presence of PCR-positive during follow-up is considered to be covid-19 infection; PCR-Negative and no symptoms of infection during the follow-up period are considered not infected; participants with symptoms but no PCR test were excluded from the study.Participants were divided into three groups according to the RT-PCR results and the presence or absence of symptoms of infection during follow-up. pentacam (Pentacam HR, Oculus, Wetzlar, Germany) was performed during follow-up and the results were recorded,and the data was statistically managed and compared.

Study Timeline

• Study Start: 2022-11-25
• Primary Completion: 2023-01-20
• Study Completion: 2023-01-20
• Status Verified: 2023-05
• Study First Submitted: 2023-05-08
• Study First Submitted QC: 2023-05-27
• Last Update Submitted: 2023-05-27
• Study First Posted: 2023-05-31
• Last Update Posted: 2023-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

Not provided

Exclusion Criteria

1. corneal disease;
2. ocular trauma;
3. Pregnant and lactating women;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The value of cornea thickness	1 months	The value of cornea thickness from pentacam during follow-up were compared, includig the thinnest point, apex of the cornea.
The value of cornea backscatter	1 months	The value of cornea backscatter from pentacam during follow-up were compared, including anterior layer，central layer and posterior
The value of cornea aberration	1 months	The value of aberration data from pentacam during follow-up were compared, including coma, spherical aberration, defocus, and astigmatism

Trial Locations

Locations (1)

Tianjin Eye Hospital; 🇨🇳 Tianjin, Tianjin, China