Effects of Acute Cannabidiol (CBD) Supplementation on Nutrient Metabolism and Energy Intake in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Energy intake
研究概览
简要总结
CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether a single 300 mg dose of CBD can improve metabolic control following a meal and/or reduce energy intake at a subsequent meal. Healthy, adult volunteers will complete two conditions in a crossover design, comparing outcomes following both CBD and placebo supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Self-report as healthy, male or female, aged 18-50, body mass index ≥18.5 and <30.0
排除标准
- •Currently engage in >10 hours moderate or vigorous intensity physical activity per week
- •Have consumed CBD or cannabis at all within the past two months
- •Have used CBD or cannabis regularly (>2x in a week) within the past four months
- •Are suffering from any clinically significant illness
- •Have regularly used tobacco within the previous 6 months (> 2/week)
- •Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers)
- •Have given a standard blood donation within 30 days of screening
- •Are currently pregnant or lactating
- •Are allergic/intolerant to any ingredients in food items provided during the study
结局指标
主要结局
Energy intake
时间窗: ~5-30 minutes (time taken to eat a single meal)
Self-selected energy intake at an ad libitum mixed meal
Postprandial Glycaemia
时间窗: 3 hours
Plasma glucose response to a mixed meal (plasma glucose concentrations and area under curve)
Postprandial Triglyceridaemia
时间窗: 3 hours
Plasma triglyceride response to a mixed meal (plasma triglyceride concentrations and area under curve)
次要结局
- Postprandial Insulinaemia(3 hours)
研究者
Lewis James
Senior Lecturer in Nutrition
Loughborough University