Radiotherapy and Androgen Deprivation In Combination After Local Surgery

Phase 3

Completed

• Conditions: Prostate cancer; Cancer

• Registration Number: ISRCTN40814031
• Lead Sponsor: MRC Clinical Trials Unit at UC

Brief Summary

2007 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/17359901 protocol 2022 Abstract results in https://oncologypro.esmo.org/meeting-resources/esmo-congress/duration-of-androgen-deprivation-therapy-adt-with-post-operative-radiotherapy-rt-for-prostate-cancer-first-results-of-the-radicals-hd-trial-i RADICALS-HD (added 08/12/2022) 2020 Other publications in https://pubmed.ncbi.nlm.nih.gov/33002431/ (added 08/12/2022) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35810050/ RADICALS-HD (added 08/12/2022) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33002429/ RADICALS-RT (added 08/12/2022) 2024 Results article in https://doi.org/10.1016/s0140-6736(24)00548-8 RADICALS-HD (added 20/05/2024) 2024 Results article in https://doi.org/10.1016/s0140-6736(24)00549-x RADICALS-HD (added 20/05/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2006-10-31
• Study Completion: 2022-07-28
• Last Update Posted: 3 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 4236

Inclusion Criteria

Patient has undergone radical prostatectomy

Exclusion Criteria

1. Androgen deprivation prior to radical prostatectomy
2. Bilateral orchidectomy
3. Prior pelvic radiotherapy
4. Other active malignancy likely to interefere with protocol treatment or follow-up
5. Known distant metastases from prostate cancer

Study & Design

• Study Type: Interventional
• Study Design: Not specified