Amnioreduction in Polyhydramnios

Not yet recruiting

• Conditions: Polyhydramnios

• Registration Number: NCT07067593
• Lead Sponsor: Assiut University

Brief Summary

The aim of this work is to review the indications, procedural complications and outcomes of amnioreduction in pregnancies complicated by polyhydramnios.

Detailed Description

Polyhydramnios is the presence of excessive amniotic fluid in the amniotic sac and it's prevalence reaches 2% of all pregnancies . Polyhydramnios is diagnosed based on ultrasound criteria, as an amniotic fluid index (AFI) \>25 cm or maximal vertical pocket \> 8 cm . There is a recognized association of polyhydramnios and adverse pregnancy outcomes, including perinatal death, fetal abnormality and preterm birth . Management of the pregnancy can be problematic, particularly in severe cases, due to issues surrounding maternal discomfort and the risk of preterm birth. Amnioreduction, widely used in the management of polyhydramnios, is an option available to palliate maternal symptomatology and potentially prolong the pregnancy . Previous publications have shown a reduction in the risk for premature rupture of membranes and preterm labor decrease, placental perfusion improvement, and relief of maternal discomfort following amnioreduction

Study Timeline

• Status Verified: 2025-07
• Study First Submitted: 2025-07-06
• Study First Submitted QC: 2025-07-15
• Last Update Submitted: 2025-07-15
• Study First Posted: 2025-07-16
• Last Update Posted: 2025-07-16
• Study Start: 2025-08-01
• Primary Completion: 2026-01
• Study Completion: 2026-02-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 28

Inclusion Criteria

• Pregnant women 20- 38 weeks
• Patients with polyhydramnios

Exclusion criteria:

• Lethal fetal anomalies
• Pre labor rupture of membranes
• Placental separation
• Chorioamnionitis

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gestational age at delivery	4 months	Determine Gestational age at delivery in polyhydramnios patients . Increased age is good.
Rate of PROM	4 months	Number of cases developed PROM

Trial Locations

Locations (1)

Women's Health Hospital; 🇪🇬 Assiut, Egypt