Bronchoscopy-Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Diseases
- Sponsor
- University of North Carolina, Chapel Hill
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- The goal of this project is to define the effect of smoking on key aspects of airway biology. These studies will also provide crucial & novel definition of airway biology in smokers against which COPD & CF patients will be compared.
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non-smokers. These samples will be used for test-tube studies to explore mechanisms of diseases of the respiratory tract, and to compare the samples between people who smoke cigarettes and people who don't. Obtaining these samples requires an invasive procedure called "bronchoscopy".
Investigators
Raymond Coakley, MD
Assistant Professor of Medicine
University of North Carolina, Chapel Hill
Eligibility Criteria
Inclusion Criteria
- •Current cigarette smokers
- •Must be otherwise healthy with no chronic illness
Exclusion Criteria
- •Smoking related lung disease (including bronchitis)
Outcomes
Primary Outcomes
The goal of this project is to define the effect of smoking on key aspects of airway biology. These studies will also provide crucial & novel definition of airway biology in smokers against which COPD & CF patients will be compared.
Time Frame: At the time of bronchoscopy