Assessment of Lipid Profile in Juvenile Systemic Lupus Erythematosus

Recruiting

• Conditions: Systemic Lupus Erythematosus
• Interventions: Other: lipid profile

• Registration Number: NCT06151990
• Lead Sponsor: Assiut University

Brief Summary

. To determine pattern and frequency of dyslipoproteinemia in patients with newly diagnosed juvenile SLE and to assess effect of disease activity on lipid profile of patients with juvenile SLE.

Detailed Description

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and the presence of circulating autoantibodies against self-antigens leading to inflammatory damage of many target organs including the skin, joints, kidneys, blood cells, blood vessels, and the central nervous system.Premature atherosclerosis has been recognized as an important issue for patients with SLE since the mid-1970s. Among the traditional risk factors of atherosclerosis, a history of smoking, diabetes, hypertension, and abnormal lipid profile have been shown to be important (7). In patients with juvenile SLE, smoking, diabetes, and uncontrolled hypertension are not common and therefore abnormal lipid profiles may be the most important risk factor.The lipid profile of both children and adults with SLE is the result of a combination of the influences of active disease, therapies, and genetics. The best way to determine the maximal potential effect of disease activity itself would be to examine patients at the time of presentation of SLE, when they are likely to have high disease activity but no effect of corticosteroid therapy.Studies in patients with active SLE suggested that there is a distinct pattern of lipid abnormalities of increased very low-density lipoprotein (VLDL) and triglycerides and decreased high-density lipoprotein (HDL-C), cholesterol and apolipoprotein A1 levels ("active SLE pattern")

Study Timeline

• Status Verified: 2023-09
• Study First Submitted: 2023-11-13
• Study First Submitted QC: 2023-11-21
• Last Update Submitted: 2023-11-21
• Study First Posted: 2023-11-30
• Last Update Posted: 2023-11-30
• Study Start: 2023-12
• Primary Completion: 2025-09
• Study Completion: 2025-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

1. Patients who are diagnosed according to 2019 European League against Rheumatism (EULAR) /American College of Rheumatology (ACR) SLE classification criteria .
2. Patients diagnosed with jSLE between 5 and 18 years of age

Exclusion Criteria

• 1. Patients on lipid lowering drugs for any other reason. 2. Patients with other autoimmune disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
newly diagnosed juvenile systemic lupus erythematosus	lipid profile	-
old cases of juvenile systemic lupus not in activity(controlled)	lipid profile	-
old cases of juvenile systemic lupus in activity	lipid profile	-

Primary Outcome Measures

Name	Time	Method
lipid profile	2 years	effect of disease activity on lipid profile of patients with JSLE

Trial Locations

Locations (1)

Assiut university; 🇪🇬 Assiut, Egypt