Estimation of Functional Liver Reserve in Patients With Hepatocellular Carcinoma in Cirrhosis: the Value of Preoperative Cholinesterases

University of Milan1 个研究点分布在 1 个国家目标入组 181 人开始时间: 2009年4月17日最近更新: 2009年4月17日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Milan
入组人数: 181
试验地点: 1
主要终点: The primary outcome was to investigate the value of preoperative cholinesterases in predict postoperative adverse outcome after hepatic resection for hepatocellular carcinoma in cirrhosis.

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Estimation of functional liver reserve in patients with hepatocellular carcinoma (HCC) in cirrhosis is of paramount importance to properly select candidates for surgical resection. Together with the value of bilirubin, the presence/absence of ascites and esophageal varices, and the rate of residual liver volume, which are our current parameters to measure functional liver reserve, the investigators sought to investigate the value of preoperative cholinesterases (CHE) in predict postoperative adverse outcome after hepatic resection for HCC.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Retrospective

入排标准

年龄范围: 18 Years 至 90 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Total bilirubin < 2 mg/dl
•No esophageal varices, or esophageal varices eradicated by endoscopy
•Liver volume:
•residual liver volume > or = 40% if total bilirubin < 1 mg/dl
•residual liver volume > or = 50% if total bilirubin between 1 and 1.5 mg/dl
•only limited resection if total bilirubin > 1.5 mg/dl
•Portal vein embolization was selected in any case in whom RLV did not fit the previous requirements.

排除标准

•Total bilirubin > 2 mg/dl
•Refractory ascites
•Esophageal varices

结局指标

主要结局

The primary outcome was to investigate the value of preoperative cholinesterases in predict postoperative adverse outcome after hepatic resection for hepatocellular carcinoma in cirrhosis.

次要结局

未报告次要终点

研究者

发起方

University of Milan

申办方类型

Other

研究点 (1)

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