Insulin Secretion in Healthy, in Obese and in Obese Type 2 Diabetic Patients Undergoing Bariatric Surgery
Not Applicable
- Conditions
- Type 2 diabetes. Beta-cell Dysfunction. Bariatric Surgery.C18.452.394.750.149
- Registration Number
- RBR-9kdzdv
- Lead Sponsor
- niversidade Estadual de Campinas
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- recruitment completed
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
Female, older than 20 years, being in premenopausal period, type 2 diabetic patient using only oral anti-diabetic medication or no medication for diabetes, weight variation less than 5% in the last 3 months; capacity to understand the procedures of the study and voluntarily agree to participate in the study by signing the consent form.
Exclusion Criteria
Patients taking insulin or drugs with effects on insulin secretion; BMI greater than or equal to 18.5 kg / m²; history of liver disease such as cirrhosis or chronic active hepatitis; alteration of renal function, a recent history of cancer, use of oral corticosteroids or injected by more than 14 consecutive days in the last 3 months.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute improvement on beta-cell function one month after biliopancreatic diversion surgery assessed by hyperglycemic clamp test and by the oral glucose tolerance test
- Secondary Outcome Measures
Name Time Method Improvement on beta-cell function one year after biliopancreatic diversion surgery assessed by hyperglycemic clamp test and by the oral glucose tolerance test