Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery
Completed
- Conditions
- Post Operative Cognitive Dysfunction
- Interventions
- Procedure: Elective Orthopedic Surgery
- Registration Number
- NCT04267328
- Lead Sponsor
- HealthPartners Institute
- Brief Summary
Post-operative cognitive dysfunction (POCD) is a common concern for aging patients undergoing elective orthopedic surgery and significantly effects health outcomes. This study aims to evaluate the incidence of and risk factors associated with post-operative cognitive dysfunction in aging patients without prior history for mild cognitive impairment or dementia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 47
Inclusion Criteria
- Age ≥50 and ≤90
- Any patient undergoing elective orthopedic surgery for hip, knee, or shoulder replacement (as defined by diagnostic codes: M16.0, M16.12, M16.11, M17.0, M17.12, M17.11, M19.011, M19.012)
Exclusion Criteria
- History of cognitive impairment of dementia
- Montreal cognitive assessment (MoCA) <26
- History of Parkinson's disease, progressive supranuclear palsy, corticobasal degeneration, normal pressure hydrocephalus, Huntington's disease, stroke, seizure disorder, brain tumor, or brain surgery
- History of surgery requiring anesthesia within the past 3 months
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients having surgery Elective Orthopedic Surgery Older adults undergoing elective orthopedic surgery.
- Primary Outcome Measures
Name Time Method Presence of Post Operative Cognitive Dysfunction (POCD) 3 months Defined as a decline of 1.5 or greater standard deviation on any one of the cognitive test performed from baseline to three-months post surgery. Score range: 0-100. A higher score indicates more cases of incident of POCD.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
HealthPartners Neuroscience Center
🇺🇸Saint Paul, Minnesota, United States