NCT00898378已完成不适用
Cancer Care Engineering of Colorectal Cancer - OMICs Pilot Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 551
- 试验地点
- 1
- 主要终点
- Creation of an OMIC profile to predict the risk of colorectal cancer (CRC)
研究概览
简要总结
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer, patients with colorectal polyps and from patients without polyps may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at biomarkers in blood and tissue samples from patients with colorectal cancer or colorectal polyps and from patients without polyps (healthy volunteers).
详细描述
OBJECTIVES:
Primary
- Perform metabolomic, lipidomic, glycoproteomic, proteomic, and genomic (OMIC) profiling using blood and tissue samples from patients with colorectal cancer (CRC) or colorectal adenomatous polyps and from patients without polyps.
- Create an OMIC profile to predict the risk of CRC based on differences observed between patients with CRC, patients with colorectal adenomatous polyps, and patients without polyps.
Secondary
- Create an OMIC profile to predict response and toxicity to specific chemotherapies, biological therapies, and radiotherapy for CRC.
- Utilize a novel knowledge discovery tool (BioMap) based on literature mining and, in the future, utilize the results of the OMIC analyses to identify interactive molecular pathways that underlie the development and progression of CRC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Creation of an OMIC profile to predict the risk of colorectal cancer (CRC)
时间窗: End of Study
Metabolomic, lipidomic, glycoproteomic, proteomic, and genomic (OMIC) profiling
时间窗: End of Study
次要结局
- Creation of an OMIC profile to predict response and toxicity to specific therapies for CRC(End of Study)
- Identification of interactive molecular pathways that underlie the development and progression of CRC(End of Study)
研究者
研究点 (1)
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