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Prevalence of FGIDs and Probiotics Study

Not Applicable
Recruiting
Conditions
Infant Conditions
Functional Gastrointestinal Disorders
Interventions
Other: Placebo
Dietary Supplement: Biogaia
Registration Number
NCT06309199
Lead Sponsor
Chulalongkorn University
Brief Summary

This is a study to evaluate the prevalence of FGIDs in infants using the Thai version of Rome IV diagnostic questionnaire for functional gastrointestinal disorders in infants and evaluate the efficacy of Limosilactobacillus reuteri DSM 17938 to prevent FGIDs in infants.

Detailed Description

This is a randomized controlled trial study about the the efficacy of Lactobacillus reuteri DSM 1987 to prevent FGIDs in healthy infants and the effect to gut microbiota diversity. The incidence of FGIDs in Thai infant using Thai version of ROME IV questionnaire (authorized by Rome Foundation) for infant and toddler and the associated factors of FGIDs also evaluate.

Population: target and control populations are the healthy infants born at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, and can come to follow up at the hospital at 1, 2, 4, and 12 months of age Inclusion criteria

1. Healthy and term (GA 37-41 weeks) infants

2. Appropriate weight for age

3. APGAR score more than 8 at 10 minutes of life

4. Normal physical examination

5. Mothers have no previous probiotics use Methodology

* Participants were double-blinded randomized using computer generation in block of four

* Target population were received Limosilactobacillus reuteri DSM 17938 5 drops (0.185 mL) per day for 60 days

* Control population were received mixture of sunflower oil and MCT oil 5 drop (0.185 mL) per day for 60 days

* There were 5 visits at birth, 1, 2, 4, 12 months of life: the demographic data/Rome IV questionnaire for FGIDs in infant and associated factors with FGIDs record, physical examination and stool collection

* Research assistance will telephone to them to take the Rome IV questionnaire for FGIDs at 3, 6, 9 months of life

Biological specimen collection Stool will be collected by rectal stimulation in each visit. The amount of \>5 gm stool will be preserved in DNA and kept at -80 °C. All stool specimen will be processed the DNA extraction (DNA \> 40 microlitre with concentration \>50 ng/L). The DNA extraction for further amplification 16S rRNA using Illumina. The rest of the specimen will be kept up to 10 years for further evaluation.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
512
Inclusion Criteria
  1. Healthy and term (GA 37-41 weeks) infants
  2. Appropriate weight for age
  3. APGAR score more than 8 at 10 minutes of life
  4. Normal physical examination
  5. Mothers have no previous probiotics use
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Exclusion Criteria
  1. not willing to anticipate in the study
  2. cannot come to follow-up until 1 year of age
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
PlaceboPlaceboSunflower oit and MCT oil were paced into a container. Infants will received 5 drops per day in the morning for 60+/- 20 days
ProbioticsBiogaiaLimosilactobacillus reuteri DSM 17938 with sunflower oil and MCT oil were packed into a container. Infants will received 5 drops per day in the morning for 60 +/- 20 days
Primary Outcome Measures
NameTimeMethod
The prevalence of functional gastrointestinal disorders in the treatment groupat birth, 1 month, 2 months, 4 months and 1 year (5-time points)

Functional gastrointestinal disorders (colic, regurgitation, constipation, dyschazia and rumination) were assessed using the Thai version of Rome IV diagnostic questionnaire for neonates and toddlers

Secondary Outcome Measures
NameTimeMethod
The prevalence of functional gastrointestinal disorders in the placebo groupat birth, 1 month, 2 months, 4 months and 1 year (5-time points)

Functional gastrointestinal disorders (include colic, regurgitation, constipation, dyschazia and rumination) were assessed using the Thai version of Rome IV diagnostic questionnaire for neonates and toddlers

Trial Locations

Locations (1)

Maha Chakri Sirindhorn Clinical Research Center (Chula CRC)

🇹🇭

Bangkok, Thailand

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