Effect of probiotics on multiple trauma patients

Phase 3

• Conditions: Traumatic patients.; Unspecified multiple injuries

• Registration Number: IRCT20211006052684N1
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Patients who are admitted to the intensive care unit (ICU) due to trauma
Patients older than 18 and younger than 70 years
Patients who are expected to stay in the ICU for 7 days or more

Exclusion Criteria

Patients who do not consent to participate in the study.
Patients who have absolute contraindication to enteral feeding or the use of probiotics.
Pregnant patients
Patients with an APACHE II score of more than 34 (mortality rate of 85% and higher)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantitative C-reactive protein (QCRP). Timepoint: Before and 7 days after the beginning of intervention. Method of measurement: Laboratory Kit.;The Acute Physiology and Chronic Health Evaluation II score (APACHE II). Timepoint: Before and 7 days after the beginning of intervention. Method of measurement: Based on the APACHE II score table.;The Simplified Acute Physiology Score (SAPS II). Timepoint: Before and 7 days after the beginning of intervention. Method of measurement: Based on the SAPS II score table.;Sequential Organ Failure Assessment (SOFA). Timepoint: Before and 7 days after the beginning of intervention. Method of measurement: Based on the SOFA score table.

Secondary Outcome Measures

Name	Time	Method
28-day mortality. Timepoint: 28 days after the start of the intervention. Method of measurement: Questionnaire.;Time to discharge. Timepoint: At the time of patient discharge. Method of measurement: Total days from the start of intervention to discharge.