To study the efficacy of oral corticosteroid compared to intravenous corticosteroid as a first line therapy for treatment of Acute severe ulcerative colitis. - NI

PGIMER0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年4月1日

试验速览

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•1. Patients with Hb less than 8g/dl
•2. Patients with serum albumin levels less than 2.5 g/dl
•3. Patients with sepsis precluding the use of corticosteroids with any two of the three criteria Fever Temp more than 100 F, TLC less than 4000/cumm or more than 12000/cumm, raised procalcitonin (more than 1 pg/dL)
•4. Patients having more than 10 blood mixed stools
•5. Patients having megacolon or toxic megacolon on abdominal x-ray
•6. Patients with abdominal tenderness or features of impending perforation
•7. Patients who have had any flare requiring corticosteroids in the preceding 3 months from inclusion
•8. Patients with prior history of failure of response to intravenous corticosteroids for severe flare of ulcerative colitis
•9. Patients already receiving oral corticosteroid at the time of inclusion
•10. Patient who have received more than 1 dose of IV Corticosteroid during index admission
•11. Poor performance status (ECOG 3)
•12. Patients with suspected or proven malignancy of any organ and GI malignancy
•13. Inclusion any other drug trial in last 03 months affecting outcome of current trial
•14. Not willing to participate in the trial and sign the informed consent
•15. Pregnant and lactating females
•16. Patients with prior colonic surgery due to any cause.

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