The University of Hong Kong Neurocognitive Disorder Cohort

• Conditions: Neurocognitive Disorder; Vascular Dementia; Alzheimer Dementia; Age-related Cognitive Decline; Mild Cognitive Impairment
• Interventions: Diagnostic Test: Neurocognitive battery; Diagnostic Test: MRI; Biological: Blood tests; Diagnostic Test: EEG with event-related potential (ERP); Diagnostic Test: Amyloid PET CT

• Registration Number: NCT03275363
• Lead Sponsor: The University of Hong Kong

Brief Summary

The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment.

Detailed Description

The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment, and in particular the biomarkers that predict cognitive and functional decline.

Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests.

The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-09-01
• Status Verified: 2017-09
• Study First Submitted: 2017-09-04
• Study First Submitted QC: 2017-09-05
• Last Update Submitted: 2017-09-05
• Study First Posted: 2017-09-07
• Last Update Posted: 2017-09-07
• Primary Completion: 2022-01-01
• Study Completion: 2022-01-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).

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Exclusion Criteria

• Severe Parkinson's disease, major depressive disorder or severe psychiatric conditions, significant communication difficulties (e.g. aphasia, deafness), terminal cancer or likely end-of-life in the next 12 months.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cognitively normal controls (CNC)	Neurocognitive battery	No subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Cognitively normal controls (CNC)	MRI	No subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Cognitively normal controls (CNC)	Blood tests	No subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Cognitively normal controls (CNC)	EEG with event-related potential (ERP)	No subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Mild cognitive impairment (MCI)	MRI	Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described
Alzheimer's dementia	Blood tests	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Probable Alzheimer's disease All interventions as described except EEG with ERP
Alzheimer's dementia	Neurocognitive battery	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Probable Alzheimer's disease All interventions as described except EEG with ERP
Vascular dementia	Neurocognitive battery	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Related to stroke / cerebrovascular disease All interventions as described except EEG with ERP
Vascular dementia	MRI	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Related to stroke / cerebrovascular disease All interventions as described except EEG with ERP
Vascular dementia	Amyloid PET CT	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Related to stroke / cerebrovascular disease All interventions as described except EEG with ERP
Subjective cognitive decline (SCD)	Neurocognitive battery	Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Subjective cognitive decline (SCD)	MRI	Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Mild cognitive impairment (MCI)	Blood tests	Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described
Alzheimer's dementia	MRI	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Probable Alzheimer's disease All interventions as described except EEG with ERP
Vascular dementia	Blood tests	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Related to stroke / cerebrovascular disease All interventions as described except EEG with ERP
Subjective cognitive decline (SCD)	Blood tests	Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Subjective cognitive decline (SCD)	EEG with event-related potential (ERP)	Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Subjective cognitive decline (SCD)	Amyloid PET CT	Subjective memory complaints Normal HK-MoCA Normal instrumental ADL All interventions as described
Mild cognitive impairment (MCI)	Neurocognitive battery	Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described
Alzheimer's dementia	Amyloid PET CT	Subjective memory complaints Low HK-MoCA Poor instrumental ADL Probable Alzheimer's disease All interventions as described except EEG with ERP
Mild cognitive impairment (MCI)	EEG with event-related potential (ERP)	Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described
Mild cognitive impairment (MCI)	Amyloid PET CT	Subjective memory complaints Low HK-MoCA Normal instrumental ADL All interventions as described

Primary Outcome Measures

Name	Time	Method
Cognitive decline	1 year	Change in total HK-MoCA score between baseline and follow-up

Secondary Outcome Measures

Name	Time	Method
Functional decline	1 year	Change in Lawton's IADL score between baseline and follow-up
Neuropsychiatric decline	1 year	Change in Neuropsychiatric Index (NPI) between baseline and follow-up
Quality of life decline	1 year	Change in QoL-AD score between baseline and follow-up
Change in cognitive impairment status	1 year	Progression to mild cognitive impairment (MCI) or dementia status

Trial Locations

Locations (1)

Department of Medicine, Queen Mary Hospital, The University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong