Coronary CT Angiogram - Prognostic Value of Adverse Plaque Features in Guiding Treatment (CT-PLAQUE)

Active, not recruiting

• Conditions: Determining if the Presence of Adverse Plaque Features Identified From the CT Angiogram Can Help Determining Prognosis and Guide Treatment Options

• Registration Number: NCT07212751
• Lead Sponsor: The University of Hong Kong

Brief Summary

The study aims at determining if the presence of adverse plaque features identified from the CT angiogram can help determine prognosis and guide treatment options.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-29
• Status Verified: 2025-06
• Study First Submitted: 2025-07-07
• Study First Submitted QC: 2025-10-01
• Last Update Submitted: 2025-10-01
• Study First Posted: 2025-10-08
• Last Update Posted: 2025-10-08
• Primary Completion: 2026-06-30
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 22000

Inclusion Criteria

• Patient who is ≥ 18 years old presented with chest pain and has undergone CTA between 01-Jan-2012 and 31-Dec-2022 before treatment
• If multiple CTAs are taken, the most updated one before treatment commencement will be chosen.

Exclusion Criteria

• Patient who did not undergo cardiac CT scan due to inability to undergo cardiac CT scanning, kidney failure (serum creatinine >250 μmol/L or estimated glomerular filtration rate <30 mL/min), major allergy to contrast.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death and all-cause death	5 years after CTCA examinations

Secondary Outcome Measures

Name	Time	Method
Total plaque, total calcified plaque, total non-calcified plaque, CT-FFR	5 years after CTCA examinations

Trial Locations

Locations (1)

The University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong