Hybrid Exercise Training for Weight Loss

Not Applicable

Completed

• Conditions: Circuit-based High Intensity Interval Training; Habitual Physical Activity; Performance; Body Composition; Resting Metabolic Rate
• Interventions: Behavioral: DoIT workout; Behavioral: DoIT workout - Detraining; Behavioral: Control - No training

• Registration Number: NCT03134781
• Lead Sponsor: University of Thessaly

Brief Summary

In this study the investigators utilized a novel hybrid HIIT (high intensity interval training) exercise training approach, the Hybrid Interval Training (DoIT) workout that combines interval training, resistance exercise training and functional training in order to test the hypothesis that DoIT will be able to: i) reduce body mass, ii) improve body composition and iii) alter energy balance, of previously inactive, overweight/obese women.

Detailed Description

In a controlled randomized, two-group, repeated measures design, 65 healthy, sedentary, premenopausal overweight or obese women were randomly assigned to one of three groups: (a) a control group (C, N=21) that participated only in measurements, (b) a training group (TR, N=14) that participated in a supervised 40-week DoIT workout exercise training program and (c) a training-detraining group (TRD, N=14). During the first 20 weeks, TR and TRD followed exactly the same training protocol. At the end of this period, TR continued training for 20 more weeks whereas TRD terminated training for 20 weeks (detraining). Anthropometric, metabolic, daily nutritional intake, habitual physical activity and performance measurements were performed in all groups at baseline, at 20 weeks and 40 weeks.

Study Timeline

• Study Start: 2015-07
• Primary Completion: 2016-07
• Study Completion: 2017-04
• Study First Submitted: 2017-04-26
• Study First Submitted QC: 2017-04-26
• Study First Posted: 2017-05-01
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-25
• Last Update Posted: 2021-10-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 49

Inclusion Criteria

• (a) were sedentary (<7,500 steps/day; VO2max <30 ml/kg/min), b) premenopausal women aged 30-45 years, c) were overweight or obese class 1 (BMI=25-34.9 kg/m2), d) were non-smokers for ≥6 months before the study, e) not following a diet intervention or using nutritional supplements/medications before (≥6 months) and during the study, f) had no weight loss greater >10% of body mass ≤6 months before the study, g) participated in ≥80% of total exercise sessions, and h) had no symptoms of depression.

Exclusion Criteria

• a) a recent febrile illness, b) history of muscle lesion, c) lower limb trauma, d) signs, symptoms or diagnosis of serious health complications or physical disability or other medical condition compromising safe participation in exercise training.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Training	DoIT workout	Participated in a supervised 40-week DoIT workout exercise training program and in measurements at baseline, at 20 weeks and at 40 weeks.
Training-Detraining	DoIT workout - Detraining	Participated in a supervised 20-week DoIT workout exercise training program and then entered a 20-week detraining period. They also participated in measurements at baseline, at 20 weeks and at 40 weeks.
Control	Control - No training	Participated only in measurements at baseline, at 20 weeks and at 40 weeks.

Primary Outcome Measures

Name	Time	Method
Change in body mass	At baseline, at 20 weeks and at 40 weeks.
Change in fat mass	At baseline, at 20 weeks and at 40 weeks.	Fat mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).
Change in resting metabolic rate	At baseline, at 20 weeks and at 40 weeks.	Measured using a portable open-circuit indirect calorimeter with a ventilated hood system.
Change in body mass index	At baseline, at 20 weeks and at 40 weeks.
Change in waist circumference	At baseline, at 20 weeks and at 40 weeks.
Change in body fat.	At baseline, at 20 weeks and at 40 weeks.	Body fat assessed by whole-body dual-energy X-ray absorptiometry (DXA).
Change in hip circumference	At baseline, at 20 weeks and at 40 weeks.
Change in waist-to-hip ratio	At baseline, at 20 weeks and at 40 weeks.
Change in fat-free mass	At baseline, at 20 weeks and at 40 weeks.	Fat-free mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).
Change in exercise-induced caloric expenditure.	At baseline, at 20 weeks and at 40 weeks.	Measured using a portable indirect calorimetry system

Secondary Outcome Measures

Name	Time	Method
Change in blood lactate concentration	Pre-exercise, during the exercise and post-exercise at baseline, at 20 weeks and at 40 weeks.
Change in habitual physical activity	At baseline, at 20 weeks and at 40 weeks.	Seven-day habitual physical activity was assessed by accelerometry
Change in dietary intake	At baseline, at 20 weeks and at 40 weeks.	Assessed using 7-day diet recalls
Change in maximal strength (1RM)	At baseline, at 20 weeks and at 40 weeks.	Measured bilaterally on a horizontal leg press.
Change in maximal oxygen consumption (VO2max)	At baseline, at 20 weeks and at 40 weeks.	Assessed by a portable open-circuit spirometry system.

Trial Locations

Locations (1)

Exercise Biochemistry Laboratory, School of Physical Education & Sports Sciences, University of Thessaly; 🇬🇷 Trikala, Karies, Greece