Impact of a Multidisciplinary Consultation Program on Drug Adherence in First Oral Anticancer Treatment

Recruiting

• Conditions: Adherence to Oral Anticancer Treatment; Drug Related Toxicity; Securing Medication Management; Multidisciplinary Consultation Program
• Interventions: Device: multidisciplinary consultation program

• Registration Number: NCT04797143
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Oncology management has changed dramatically over the last decade with the approval and rapid adoption of newly targeted oral oncology medications. The movement to oral oncology medications has altered the balance of risks and adverse effects (AEs) in the treatment of cancer care. These treatments are associated with a different constellation of AEs and drug interactions. Patients receiving treatment with oral anticancer treatment (OAT) encounter several barriers to adherence, which may include limited access to specialty medications, severe adverse effects, complex medication regimens, and special handling precautions. Medication nonadherence not only reduces the efficacy of drug therapy but also has the potential to increase healthcare expenditures due to disease-related hospitalizations. The purpose of this study is to evaluate the drug adherence in cancer patients, using the medication possession ratio (MPR), before and after the implementation of a multidisciplinary consultation program (MCP), on initiation of OAT.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-11
• Study First Submitted: 2021-03-11
• Study First Submitted QC: 2021-03-11
• Study First Posted: 2021-03-15
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-01
• Last Update Posted: 2025-04-02
• Primary Completion: 2026-03
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• French speaking patients with a newly diagnosed or relapsed cancer, regardless of location and introduction of oral anticancer treatment

Exclusion Criteria

• patients treated with hormone therapy only
• Patient with severe psychiatric disorders
• patient who does not speak the French language

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
intervention group	multidisciplinary consultation program	intervention group after implementation of a MCP

Primary Outcome Measures

Name	Time	Method
medication possession ratio (MPR)	one year	The MPR makes it possible to determine the percentage of days of treatment covered by pharmacy dispensing. A patient is generally considered observant if MPR is greater than or equal to 80%.

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France