LOXL1 Polymorphism in Pseudoexfoliation Syndrome

• Conditions: Pseudoexfoliation Syndrome

• Registration Number: NCT01515735
• Lead Sponsor: Samsung Medical Center

Brief Summary

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.

Detailed Description

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.

And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing.

Study Timeline

• Study Start: 2011-12
• Status Verified: 2012-01
• Study First Submitted: 2012-01-18
• Study First Submitted QC: 2012-01-23
• Last Update Submitted: 2012-01-23
• Study First Posted: 2012-01-24
• Last Update Posted: 2012-01-24
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Clinical diagnosis of Pseudoexfoliation

Exclusion Criteria

• medical condition that peripheral blood sampling cannot be done

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Genotypes of the three single nucleotide polymorphisms of LOXL1 (rs1048661, rs3825942, rs2165241)	about 1 year (when all patients were recruited)	Genotypes of the three single nucleotide polymorphisms of LOXL1 were analyzed by direct sequencing, after obtained from the peripheral blood sampling from patients.

Trial Locations

Locations (1)

Samsung medical center; 🇰🇷 Seoul, Korea, Republic of