NCT07434635RecruitingPhase 4
APPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes
University of California, San Francisco1 site in 1 country62 target enrollmentStarted: March 10, 2026Last updated:
Interventions
Trial Snapshot
- Phase
- Phase 4
- Status
- Recruiting
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- Pain score on the Visual Analog Scale (VAS)
Study Overview
Brief Summary
The study will evaluate whether atropine eyedrops are beneficial when used after certain eye surgeries.
Detailed Description
Atropine eyedrops are often used after certain eye surgeries. This study will compare several outcomes following surgery in patients either using or not using this treatment.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patient undergoing vitrectomy surgery
- •able to give informed consent
Exclusion Criteria
- •post-operative eyedrop regimens that include topical non steroidal anti-inflammatory medications
- •subjects with altered post-operative eyedrop schedule for enhanced inflammation control
- •documented allergy to atropine
Arms & Interventions
Control
No Intervention
No atropine
Experimental
Experimental
Participant uses atropine eyedrops
Intervention: Atropine 1% (Drug)
Outcomes
Primary Outcomes
Pain score on the Visual Analog Scale (VAS)
Time Frame: 1 month
Whether atropine use impacts post-operative pain score on the standard Visual Analog Scale (VAS)
Secondary Outcomes
- Anterior chamber inflammation (aqueous cell and flare)(1 month)
- Cystoid macular edema detected by optical coherence tomography(1 month)
- Time to visual recovery(1 month)
- Intraocular pressure(1 month)
- Posterior synechiae formation(1 month)
Investigators
Study Sites (1)
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