A multisite clinical trial of repetitive transcranial magnetic stimulation (rTMS) for social communication in autism spectrum disorder (ASD).

Not Applicable

Recruiting

• Conditions: Autism spectrum disorder; Mental Health - Autistic spectrum disorders

• Registration Number: ACTRN12620000890932
• Lead Sponsor: Deakin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-09-10
• Last Update Posted: 13 March 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

•Aged between14-40 years
•Diagnosed with autism spectrum disorder (ASD) based on DSM-5 criteria, and confirmed via Autism Diagnostic Observation Schedule – Second Edition (ADOS-2)

Exclusion Criteria

•History of seizure/s or epilepsy
•History of serious head injury
•Contraindication to magnetic resonance imaging (MRI)
•Formal verbal intelligence quotient VIQ assessment <55, as determined by Wechsler Abbreviated Scale of Intelligence (WASI-2) or another standardised cognitive assessment
•Comorbid neurological or psychiatric diagnosis not commonly associated with ASD (e.g., psychosis)
•Unstable medical condition
•Unstable medication regime, or medication contraindicated for TMS
•Substance use/abuse disorder
•Concurrent treatment targeting social communication
•Evidence of significant epileptiform activity on EEG (e.g., seizures on EEG, runs of epileptiform discharges)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in social relating as measured by the Social Responsiveness Scale - 2nd Edition (SRS-2).[1-month post-treatment completion (compared with baseline).]