Multi-centre randomised control trial comparing the clinical and cost effectiveness of trans-foraminal epidural steroid injection to surgical microdiscectomy for the treatment of chronic radicular pain secondary to prolapsed intervertebral disc herniation: Nerve rootblock versus surgery (NERVES)

The Walton Centre NHS Foundation Trust (UK)0 sites163 target enrollmentJune 5, 2014

Overview

Registry

who.int

Start Date

June 5, 2014

End Date

July 9, 2019

Last Updated

4 years ago

Study Type

Interventional

Sex

All

Sponsor

The Walton Centre NHS Foundation Trust (UK)

•As of 19/05/2016:
•1\. Diagnosed lower extremity radiculopathy (sciatica)
•2\. Sciatica secondary to prolapsed intervertebral disc (PID) (proven on MRI)
•3\. Duration of symptoms between 6 weeks and 12 months
•4\. Leg pain non\-responsive to conservative, non\-invasive management
•5\. Age 16 – 65 years
•6\. Patient has attempted at least one form of conservative (non\-operative) treatment\* but this has not provided adequate relief of patient’s pain/symptoms
•7\. Patient willing and able to give consent
•\*including but not limited to; medication, physiotherapy, modification of daily activities
•Previous inclusion criteria:

•As of 19/05/2016:
•1\. Serious neurological deficit (e.g. foot\-drop/possible cauda\-equina compression)
•2\. Previous spinal surgery at the same intervertebral disc (level)
•3\. Sciatica presentation for longer than 12 months
•4\. Age \< 16
•5\. Age \> 65
•6\. Patient has not attempted any form of conservative treatment
•7\. Any patient who has a contraindication for surgery and/or injection
•8\. Patient known to be pregnant
•Previous exclusion criteria: