Standard Cross-linking Versus Accelerated Photoactivated Chromophore Cross-linking (PACK-CXL) for Treatment of Infectious Keratitis: A Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 1
- 主要终点
- Corneal healing
研究概览
简要总结
To compare between SCXL and ACXL for treatment of infectious keratitis
详细描述
Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode (Group A). Accelerated CXL 11 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode (Group B).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Fungal infectious keratitis
- •bacterial infectious keratitis
- •Must be not responding to medication
排除标准
- •Viral keratitis
- •Pregnancy and lactation
研究组 & 干预措施
Standard CXL
Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode.
干预措施: PACK-CXL (Procedure)
Accelerated CXL
Accelerated epithelium-off CXL, 12 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation continuous mode.
干预措施: PACK-CXL (Procedure)
结局指标
主要结局
Corneal healing
时间窗: 3 months
Reepithelization of corneal ulcer which is measured in mm by slitlamp examination
Corneal edema
时间窗: 3 months
measurement of corneal edema by measurement of the corneal thickness in um by Optical Coherent Tomography
次要结局
未报告次要终点
研究者
Prof. Mohammed Iqbal
Assistant Professor of Ophthalmology
Sohag University