Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients

Completed

• Conditions: Critical Illness; Hyperglycemia

• Registration Number: NCT01796847
• Lead Sponsor: University of Roma La Sapienza

Brief Summary

Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood. The Phosphatase and Tensin homolog (PTEN) is known to influence glucose homeostasis by interfering in intracellular insulin signaling.

Aim of this study is to ascertain whether differential expression of PTEN in critically ill patients correlates with glycemic variability and clinical outcome.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-12
• Study First Submitted: 2013-02-11
• Study First Submitted QC: 2013-02-21
• Study First Posted: 2013-02-22
• Primary Completion: 2014-12
• Study Completion: 2015-05
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-03
• Last Update Posted: 2017-11-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• trauma
• provision informed consent

Exclusion Criteria

• diabetes
• impaired fasting glucose levels

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Length of ICU stay	Day 1 up to day 28

Secondary Outcome Measures

Name	Time	Method
Glycemic variability as expressed by standard deviation of the glycemia measurements	Day 1 up to day 28

Trial Locations

Locations (1)

University of Rome La Sapienza, University Hospital; 🇮🇹 Rome, Italy