Study of Analgesic Effect and Individual Sensitivity Differences of Opioid Analgesics
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Surgery
- Sponsor
- Huazhong University of Science and Technology
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Mean Pressure Pain Threshold
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Purpose: This study aimed to find a quick and timely way to investigate the individual variation of efficacy of opioid analgesic in Chinese patients undergoing elective surgeries. Methods: 120 female patients receiving elective surgery under general anesthesia were recruited into this study. At the time of routine intravenous anesthetic induction we observe the efficacy of opioid analgesic including analgesic effect, effects on Narco-trend index, sedative effect, effects on respiratory system, and aslo effects on cardiovascular system.
Detailed Description
Patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.
Investigators
Xianwei Zhang
Professor, MD.
Huazhong University of Science and Technology
Eligibility Criteria
Inclusion Criteria
- •Aged 20-65 years
- •Anesthesiologists (ASA) physical status I or II;
- •Within ±20% of ideal body weight;
- •Agreed to participate the research
Exclusion Criteria
- •History of chronic pain;
- •Psychiatric diseases;
- •Diabetes mellitus;
- •Severe cardiovascular diseases;
- •Kidney or liver diseases;
- •Alcohol or drug abuse (according to the criteria of DSM-IV);
- •Pregnancy or at lactation period;
- •Disagree to participate to the research
Outcomes
Primary Outcomes
Mean Pressure Pain Threshold
Time Frame: 10 minutes after the procedure
According to the measurement of pressure pain threshold after intravenous injection of opioid analgesics
Mean Value of Narco-trend Index
Time Frame: 10 minutes after the procedure
According to the measurement of Nacro-trend index after intravenous injection of opioid analgesics. Narco-trend index is from 0 to 100 which 0 represent deep sedation, and 100 represent waking state.
Secondary Outcomes
- Mean Arterial Pressure(10 minutes after the procedure)
- Mean Heart Rate(10 minutes after the procedure)
- Mean Respiratory Frequency(10 minutes after the procedure)