Study of Different Gating Techniques for PET Image of Lung and Liver Lesions

Completed

• Conditions: Lung; Nodule; Liver Metastases

• Registration Number: NCT05779865
• Lead Sponsor: Centre Hospitalier Princesse Grace

Brief Summary

Lesions blurred by respiratory motion are common in fluorine-18 PET/CT studies. To avoid these artefacts, several standard gating correction technics are available. the investigator aimed to compare the impact of different gating techniques based on phase, amplitude, elastic-motion monitored with and without pressurre sensor device on standardized uptake value (SUVmax and SUVpeak) and uptake volume (UV) measurements on different sizes of pulmonary and liver lesions. The feasability of this study will be done using anthropomorphic coupled with a motion phantom and on a series of patients.

Detailed Description

PET-CT images will be acquired on a Biograph Vision600 PET/CT, fitted with 26cm axial field of view and time of flight.

Phantom study will use an anthropomorphic TORSO phantom with a programmable motion phantom, mimicking respiratory motion (QUASAR). Spheres with various internal diameters will be introduce into the lungs (air density) adding an axial mechanical device simulating breathing movement of +/-20mm. Concentration in the spheres will be the same for all diameters. The background and liver activities will be approximatively respectively 38 and 14 MBq. This phantom will be a simulating patient only for lung lesions.

The investigator will compare 6 different PET acquisitions: standard 3min acquisition without movement as our reference of "trues SUVmax and UV", 3min acquisition with simulated breathing movement without any gating and 3min with respectively gating techniques based on phase, amplitude, elastic-motion monitored with and without pressurre sensor device.

Patient study will be on 50 consecutive patients with lung or liver nodules. 18F-FDG injection will be around 2.5 MBq/kg.

The investigator will compare 5 different PET acquisitions: standard acquisition with free respiratory movement as our reference of "trues SUVmax and UV", acquisitions with respectively gating techniques based on phase, amplitude, elastic-motion monitored with and without pressurre sensor device.

Study Timeline

• Study First Submitted: 2023-02-09
• Study Start: 2023-02-15
• Study First Submitted QC: 2023-03-09
• Study First Posted: 2023-03-22
• Primary Completion: 2023-06-01
• Status Verified: 2023-09
• Study Completion: 2023-09-21
• Last Update Submitted: 2023-09-22
• Last Update Posted: 2023-09-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• presence at least of one hepatic or lung nodule

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of the different gating systems in lung lesions visualization	Inclusion	Classification, based on a phantom and patients studies, of the different gating system in view of the volume and SUV (max and peak) modification for lung lesions

Secondary Outcome Measures

Name	Time	Method
Comparison of the different gating systems in liver lesions visualization	Inclusion	Classification, based on a patients studies, of the different gating system in view of the volume and SUV (max and peak) modification for liver lesions

Trial Locations

Locations (1)

Centre Hospitalier Princesse Grace; 🇲🇨 Monaco, Monaco